Paper Information

Journal:   JOURNAL OF COMPARATIVE PATHOBIOLOGY IRAN   WINTER 2012 , Volume 8 (NEW) , Number 4 (35); Page(s) 685 To 689.
 
Paper: 

GASTROINTESTINAL MOTILITY ABLATIVE EFFECT OF METHANOL EXTRACT OF L. HYSSOPIFOLIA IN DIARRHOEA DUE TO CASTER OIL AND 5-HT IN MICE

 
 
Author(s):  ISSABEAGLOO E.*, ZADIEH M.T.
 
* DEPARTMENT OF PHARMACOLOGY, MEDICAL SCIENCES FACULTY, TABRIZ BRANCH, ISLAMIC AZAD UNIVERSITY, TEHRAN, IRAN
 
Abstract: 

Diarrhoea is one of the most important GI tract that reduces meaningful performance of the patient. Dried whole plant parts of Ludwigia hyssopifolia were subjected to successive cold extraction with n-hexane, ethylacetate and methanol. The methanol extract (LHM), obtained as 1% yield, showed significant antidiarrheal property by reducing diarrheal episodes in castor oil and serotonin induced diarrhea in laboratory mice at a dose of higher than 100mg/kg body weight as compared to standard drug loperamide given at a dose of 66.67 mg/kg body weight. The percent reduction in diarrheal episode by 56.32 and 89.66 after castor oil challenge and 59.09 and 86.36 in serotonin induced diarrhea was observed at doses of 200mg/kg and 400mg/kg body weight of the extract respectively. The extract LHM was also found to reduce the gastrointestinal motility by 53.8% at a dose of 100mg/kg body weight as compared to control, while no remarkable inhibition of gastrointestinal motility was seen at a dose of 50mg/kg body weight of the extract.

 
Keyword(s): L. HYSSOPIFOLIA, DIARRHOEA, CASTER OIL, 5-HT, MICE
 
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