Paper Information

Journal:   JOURNAL OF COMPARATIVE PATHOBIOLOGY IRAN   WINTER 2012 , Volume 8 (NEW) , Number 4 (35); Page(s) 675 To 684.
 
Paper: 

EVALUATION OF SEROLOGICAL AND PATHOLOGICAL CHANGES AFTER PARTIAL AND COMPLETE NEPHRECTOMY AS UNI AND BILATERAL IN DOG

 
Author(s):  ABEDI GH., ALIZADEH R.*, ASGHARI A., CHERAGHZADEH A., KHANSARI M.
 
* DEPARTMENT OF SURGERY, FACULTY OF VETERINARY MEDICINE, SCIENCE AND RESEARCH BRANCH, ISLAMIC AZAD UNIVERSITY, TEHRAN, IRAN
 
Abstract: 

In many renal diseases, we have to do nephrectomy including renal cysts, hydronephrosis,   polycystic kidney, etc. Nephrectomy can cause severe side effects. In this study, the effect of nephrectomy on one of the important functions of kidney, the production of active vitamin D (1, 25-dihydroxycholecalciferol) from inactive vitamin D, has been studied. In this study 15 mixed breed healthy female dogs were divided into 3 group, including group 1 which underwent left partial nephrectomy, group 2 which underwent left total nephrectomy and group 3 which underwent left total nephrectomy and right partial nephrectomy. Blood samples were collected a day before surgery, on day of surgery and 45 days after surgery. Histopathology was done on surgery day and 45 days after it. The results indicated that there was hypertrophy in the remained kidney 45 days after surgery. Also, in group 3 calcium was lower and urea, creatinine and phosphorus were higher than the normal range. However, in group 1 and 2 they were in the normal range. The amount of vitamin D in group 3 showed significantly lower mean. Based on the results, it is recommended that in all three groups active vitamin D and calcium are used as exogenous, although vitamin D wasn’t in the normal range only in group 3.

 
Keyword(s): NEPHRECTOMY, VITAMIN D, DOG
 
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