We developed several FISH approaches to enable preimplantation genetic diagnosis of cancer predisposition syndromes. An overview of the applications and the results of those PGDs will be provided. In addition we developed several novel tools to genome wide screen for CNVs and SNPs in single cells. Those technologies are now being applied for polar body, blastomere and blastocyst screening for chromosomal imbalances. An overview of the current status of the technology will be provided. We further adapted and applied those genome wide approaches for the detection of chromosomal disorders. Both the challenges and the solutions to enable single cell genome wide CNV detection will be presented. Finally, I will show where and how the technology is ready for clinical implementation.