Paper Information

Journal:   INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY   SUMMER 2011 , Volume 5 , Number SUPPLEMENT 1; Page(s) 17 To 17.
 
Paper: 

FEMALE INFERTILITY: INDUCTION OF OVULATION IN CLOMIPHEN RESISTANT PCOD PATIENTS

 
 
Author(s):  PARSANEZHAD M.E.*
 
* DEPARTMENT OF GYNAECOLOGY AND OBSTETRICS, MEDICAL SCHOOL, SHIRAZ UNIVERSITY OF MEDICAL SCIENCES, SHIRAZ, IRAN
 
Abstract: 

Polycystic ovary syndrome (PCOS) is a heterogeneous disorder in which chronic anovulation is a common feature despite the presence of multiple micro- structures in the ovaries. A growing body of evidence has suggested that serum hyperinsulinemia and as the result hyperandrogenemia contributes to the excess ovarian androgen secretion observed in women with PCOS. The standard therapy for anovulatory women with PCOS is oral administration of clomiphene citrate (CC). However, a significant proportion of women with PCOS fails to ovulate with the use of standard dosage of CC and is called CC-resistant PCOS.
Treatment options including extended clomiphene protocol, clomiphene and dexamethasone combined therapy, insulin-sensitizing agents and /or aromatize inhibitors, as adjuvants to clomiphene citrate and gonadotropins and finally surgical management of PCOD has changed the treatment strategy. Although both standard and novel treatments were addressed in the present review, special attentions was paid to the evidence in support of the introduction of glucocorticoids and aromatize inhibitors in the management of anovulatory women with CC-resistant PCOS.

 
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