Paper Information

Journal:   AVICENNA JOURNAL OF PHYTOMEDICINE (AJP)   SPRING 2012 , Volume 2 , Number 2; Page(s) 97 To 104.
 
Paper: 

CROCIN ALLEVIATES THE LOCAL PAW EDEMA INDUCED BY HISTAMINE IN RATS

 
Author(s):  TAMADDONFARD ESMAEAL*, FARSHID AMIR ABBAS, HOSSEINI LEILA
 
* DEPARTMENT OF BASIC SCIENCES, FACULTY OF VETERINARY MEDICINE, URMIA UNIVERSITY, URMIA, I.R. IRAN
 
Abstract: 

Objective: Crocin, as an active constituent of saffron, has many biological functions including antioxidant and anti-inflammatory activities. The present study was aimed to investigate the effects of crocin and chlorpheniramine on local edema induced by histamine.
Materials and Methods: Local edema was induced by subcutaneous injection of histamine (100
ml, 0.1%) in ventral surface of right hind paw. The thickness of paw was measured at 1 h before and 1, 2, 3 h after injection of histamine, using a fine caliper. The number of neutrophils in paw tissue sections was counted 3 h after intraplantar injection of histamine.
Results: Intraperitoneal injection of crocin at doses of 100 and 200 mg/kg and chlorpheniramine at a dose of 10 mg/kg significantly (p<0.05) decreased both paw thickness and infiltration of neutrophils in paw tissues. In a combined treatment, intraperitoneal injection of an effective dose of crocin (100 mg/kg) with an ineffective dose of chlorpheniramine (2.5 mg/kg) produced a more documented response in comparison with crocin (100 mg/kg) and chlorpheniramine (2.5 mg/kg) used alone.
Conclusion: The results suggested that both crocin and chlorpheniramine suppressed histamineinduced local paw edema. Moreover, histamine H1 receptors function may be affected by crocin.

 
Keyword(s): CROCIN, CHLORPHENIRAMINE, HISTAMINE, PAW EDEMA, RATS
 
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