Paper Information

Journal:   SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES JOURNAL   OCTOBER-NOVAMBER 2012 , Volume 14 , Number 4; Page(s) 47 To 53.
 
Paper: 

THE EFFECT OF ORAL DEXTROMETHORPHAN AND PLACEBO ON THE POSTOPERATIVE PAIN SEVERITY OF ADENOTONSILLECTOMY

 
 
Author(s):  AMANI S.*, MADINEH H., KHAZRAEE H.R.
 
* MEDICAL PLANTS RESEARCH CENTER, SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, SHAHREKORD, I.R. IRAN
 
Abstract: 

Background and aims: One of the most important problematic issues in modern medicine is relieving the post operative pain. The pharmacological management of acute postoperative pain has been traditionally based on various regimens of opioids or NSAIDs. Considering the side effects of opioids and NSAIDs, it leads to think about replacement of these drugs. The aim of this study was to evaluate the effect of oral dextromethorphan in comparison to placebo on the postoperative pain severity of Adenotonsillectomy in patients between 3-12 years old.
Methods: In this clinical trial study 160 and children undergoing adenotonsillectomy were randomly divided in to four (1, 2, 3, 4) equal groups (40 patients in each group). Two hours before anesthesia, groups 1 and 2 received 0.5 mg/kg of oral dextromethorphan syrup and groups 3 and 4 received placebo.24 hours after the operation, groups 1 and 3 received 0.5 mg/kg of oral dextromethorphan syrup and groups 2 and 4 received placebo. The pain severity was evaluated by Oucher test every 6 hours. The data were analyzed using Chi square and repeated measure ANOVAs.
Results: In all groups, the most pain severity was on in the ward, and the least pain severity was 24 hours after operation. Base on these findings, the pain severity in all groups had a contrast relation with the age (P<0.05). But there was not a significant relation between the pain severity and gender. There was not a significant difference among the four groups in relation to pain severity, but the pain severity in all groups significantly reduced (P<0.05).
Conclusion: Based on the findings, oral dextromethorphan, with this dosage dose not reduce the pain severity in children.

 
Keyword(s): DEXTROMETHORPHAN, ADENOTONSILLECTOMY, PAIN
 
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