Paper Information

Journal:   IRANIAN JOURNAL OF PUBLIC HEALTH   2003 , Volume 32 , Number 4; Page(s) 59 To 63.
 
Paper: 

THE EFFECT OF NITRIC OXIDE DONOR IN DIABETIC WOUND HEALING

 
 
Author(s):  DASHTI N.*, ANSARI M., SHABANI M., VARDASTI S., MIRSALEHIAN A., NOORI M.N., HATMI Z.N.
 
* Iran
 
Abstract: 
Diabetes is characterized by a nitric oxide deficiency at the wound site. Diabetes is a factor that influences all stages of wound healing. In animals with acute experimental diabetes induced by streptozotocin (STZ), the early inflammatory responses after wounding is impaired, fibroblast and endothelial cell proliferation is reduced as well as accumulation of reparative collagen and gain in wound breaking strenght. This study investigated whether exogenous nitric oxide supplimentation with nitric oxide donor DETA NONOate could reverse impaired healing in diabetes. The results suggest nitric oxide donor DETA NONOate can reverse impaired healing associated with diabetes (P<0.001) and urinary nitrate (NO-3) output may reflect the extent of repair in this wound model (P<0.001).
 
Keyword(s): DETA NONOATE, DIABETES, WOUND HEALING
 
References: 
 
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