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Paper Information

Journal:   JOURNAL OF MEDICINAL PLANTS   December 2003 , Volume 2 , Number 8; Page(s) 17 To 26.
 
Paper: 

HYPNOTIC AND MUSCLE RELAXANT ACTIVITY OF THYMOQUINONE, THE MAJOR ACTIVE ?CONSTITUENT OF NIGELLA SATIVA L. SEEDS, AND ITS EFFECTS ON LOCOMOTOR ACTIVITY AND ?MOTOR COORDINATION IN MICE

 
 
Author(s):  PARVARDEH S., HOSSEINZADEH H.*
 
* Department of Pharmacodynamy and Toxicology, Faculty of Pharmacy,
 
Abstract: 
We have previously shown that thymoquinone, the major active constituent of Nigella sativa L. seeds, exhibited anticonvulsant effect in pentylenetetrazole model. In the present study, in order to clarify the other actions of thymoquinone, on the CNS, we investigated its hypnotic and muscle relaxant effects using pentobarbital - induced hypnosis and the traction test, respectively. Also, we evaluated the effects of thymoquinone, on locomotors activity and motor coordination using the open - field activity and the rotarod tests respectively. The results showed that thymoquinone, did not show any hypnotic effect but exerted muscle relaxation in 30% of mice treated with the dose of 80 mg/Kg i.p. In rotarod test, thymoquinone, (40 and 80 mg/Kg. i.p.) produced motor incoordination dose denendently. In open - field test, we found that thymoquinone, with lower doses (1 and 2 mg/Kg, i.p.) could suppress locomotor activity and locomotor - associated behaviors. These findings indicate that thymoquinone, has not any hypnotic effect, but produces muscle relaxation, as well as motor incoordination, and reduces the locomotor activity.
 
Keyword(s): THYMOQUINONE , NIGELLA SATIVA, HYPNOTIC, MUSCLE RELAXANT, LOCOMOTOR ACTIVITY, MOTOR COORDINATION.
 
References: 
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