Paper Information

Journal:   JOURNAL OF REPRODUCTION AND INFERTILITY   SPRING 2003 , Volume 4 , Number 2 (14); Page(s) 115 To 123.
 
Paper: 

INDUCTION OF OVULATION WITH A SINGLE DOSE OF METRODIN IN PCOS PATIENTS RESISTANT TO CLOMIPHENE CITRATE

 
 
Author(s):  AGHA HOSSEINY M.*, ALE YASIN ASHRAF, KHADEMI- A., SALEHPOUR SH.
 
* Obs & Gyn Dep., Shariati Hospital, Tehran Medical Sciences University, Tehran, Iran
 
Abstract: 

Polycystic Ovary Syndrome (PCOS) is a common cause of chronic an ovulation and is frequently associated with different clinical symptoms. The main objective of this clinical trial was to evaluate the therapeutic effects of single dose of metrodin administration to induce follicular response in PCOS patients at Shariati hospital (2001-2002). PCOS was the main cause of the infertility in selected patients. All the patients were treated with maximal dose of clomiphene citrate (150 mg/d) from the 3rd to the 7th days of their menstrual cycle while controlling with vaginal sonography for the follicular response. Sixty patients with follicular response were selected and studied we combined the previous strategy of clomiphene citrate administration with muscular injection of single dose (75 IU) of metrodin at the 3th day of cycle. The positive follicular response was the appearance of dominant with 18 mm diameters in the 14th to 16th days. In the presence of positive follicular response, 1000 IU of HCG was injected at the same day. Intercourse was allowed that night and the 2 subsequent days. Progesterone level was measured in the 21th day of the cycle, with levels equal or above the 3 ng/ml suggesting ovulation. Β-HCG level was measured in the 32th days of the cycle, if the menstruation was delayed. Te levels equal or more than 200 IU/l or significant increase in β-HCG level suggested chemical pregnancy. To confirm a normal intrauterine pregnancy, vaginal sonography monitoring of fetal heart rate were suggestive. Among total sixty patients, 31 (%51.7) had positive follicular response, 30 (%50) had ovulation and 15 had positive pregnancy tests. One patient had spontaneous abortion after positive pregnancy test and before sonography. Two patients had spontaneous abortion after positive sonography and two patients had preterm labor. Nine patients had term pregnancy. Complications were observed in four patients. The achieved data were analyzed, by fisher and X2 tests. Although there was no significant correlation between follicular response and variants such as age, BMI, infertility type or menstrual state, there was a statistically response and variants such as age, BMI, infertility type or menstrual state, there was a statistically high correlation between pregnancy rate and progesterone level 21th day of cycle (P<0.0001). The result of this study suggests that using a single dose metrodin administration, has a significant influence on follicular response, induction of ovulation and creating pregnancy.

 
Keyword(s): METRODIN, FOLLICULAR RESPONSE, POLYCYSTIC OVARIAN SYNDROME, CLOMIPHENE CITRATE, AND INFERTILITY
 
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