Paper Information

Journal:   JOURNAL OF MEDICINAL PLANTS   September 2003 , Volume 2 , Number 7; Page(s) 43 To 48.
 
Paper: 

STUDY OF ANTICONVULSANT ACTIVITY OF VALERIANA OFFICINALIS ROOTS AND RHIZOMES HYDROALCOHOLIC EXTRACT IN MICE AND RELATION TO NITRIC OXIDE

 
 
Author(s):  KARIMI GH.*, HOSSEINZADEH H., BAKHTIYARI H.
 
*  Mashhad, Iran
 
Abstract: 
The anticonvulsant effect of Valeriana officinalis roots and rhizomes hydroalcoholic extract was studied, utilizing maximal electroshock (MES) and pentylenetetrazole (PTZ) tests. In the PTZ test, the extract (0.3-3 g/kg,ip) increased the onset time of Tonic Hind Limb Extension dose - dependently. In the MES test, neither of doses showed antiseizure activity. L - NAME (1-10 mg/kg ip) reduced the anticonvulsant effect of extract in the PTZ test. The results suggest that Valeriana officinalis extract could be a candidate for treatment of petitmal seizure and nitric oxide may be involved in this effect.
 
Keyword(s): VALERIANA OFFICINALIS, PTZ, MES, NITRIC OXIDE
 
References: 
  • ندارد
 
  Persian Abstract Yearly Visit 66
 
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