Paper Information

Journal:   THE JOURNAL OF QAZVIN UNIVERSITY OF MEDICAL SCIENCES   Summer 2003 , Volume - , Number 26; Page(s) 0 To 0.
 
Paper: 

EFFECTS OF AGING ON CHOLINERGIC AND ADRENERGIC SYSTEMS RESPONSIVENESS OF RAT ISOLATED ATRIUM

 
 
Author(s):  MORTAZAVI S.R.*, JAFARI M., ABBASI E., DERAKHSHAN F.
 
* 
 
Abstract: 
Background:Aging is associated with changes in drugs responsiveness. Objective:To determine the effects of aging on cholinergic and adrenergic systems of rat isolated atrium.
Methods: In this study isolated atrium of male albino rats were prepared.
The rats were randomly selected & divided into 3 groups of 1020 days
(A), 2 months
(B) & over 6 months old
(C) (6Determining the Ed50 of acetylcholine, epinephrine, atropin & propranolol , their contraction responses were measured.
Finding: The sensitivity of muscarinie acetylcholine receptors (m-AdR__s) decreased and that of Beta-Adrenergic receptors (b#-AdR__s) increased in relation to age. EDSO of Acetylcholine of the were 9.8x 10__-8 , 1,7x 10__-4 and 1.5x 10__-4 respectively, while the ED50 of Adrenaline in the same groups of rats were 1.2x10__-6 , 1.69x10__-7 and 2.99x10__-6 respectively. The maximum responses for m-AchRs and b#-Adr__s were observed in 2-6 & 6-12 months old rats. Conclusion: The changes of responsiveness (decrease in cholinergic system & increase in adrenergic system) appear to be the result of age-related changes in cholinergic and adrenergic neuromuscular transmission.
 
Keyword(s): AGING, CHOLINERGIC, ADRENERGIC, ATRIUM, RAT
 
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