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Paper Information

Journal:   JOURNAL OF INFLAMMATORY DISEASES (THE JOURNAL OF QAZVIN UNIVERSITY OF MEDICAL SCIENCES)   Summer 2003 , Volume - , Number 26; Page(s) 0 To 0.
 
Paper: 

EFFECTS OF AGING ON CHOLINERGIC AND ADRENERGIC SYSTEMS RESPONSIVENESS OF RAT ISOLATED ATRIUM

 
 
Author(s):  MORTAZAVI S.R.*, JAFARI M., ABBASI E., DERAKHSHAN F.
 
* 
 
Abstract: 
Background:Aging is associated with changes in drugs responsiveness. Objective:To determine the effects of aging on cholinergic and adrenergic systems of rat isolated atrium.
Methods: In this study isolated atrium of male albino rats were prepared.
The rats were randomly selected & divided into 3 groups of 1020 days
(A), 2 months
(B) & over 6 months old
(C) (6Determining the Ed50 of acetylcholine, epinephrine, atropin & propranolol , their contraction responses were measured.
Finding: The sensitivity of muscarinie acetylcholine receptors (m-AdR__s) decreased and that of Beta-Adrenergic receptors (b#-AdR__s) increased in relation to age. EDSO of Acetylcholine of the were 9.8x 10__-8 , 1,7x 10__-4 and 1.5x 10__-4 respectively, while the ED50 of Adrenaline in the same groups of rats were 1.2x10__-6 , 1.69x10__-7 and 2.99x10__-6 respectively. The maximum responses for m-AchRs and b#-Adr__s were observed in 2-6 & 6-12 months old rats. Conclusion: The changes of responsiveness (decrease in cholinergic system & increase in adrenergic system) appear to be the result of age-related changes in cholinergic and adrenergic neuromuscular transmission.
 
Keyword(s): AGING, CHOLINERGIC, ADRENERGIC, ATRIUM, RAT
 
 
References: 
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+ Click to Cite.
APA: Copy

MORTAZAVI, S., & JAFARI, M., & ABBASI, E., & DERAKHSHAN, F. (2003). EFFECTS OF AGING ON CHOLINERGIC AND ADRENERGIC SYSTEMS RESPONSIVENESS OF RAT ISOLATED ATRIUM. JOURNAL OF INFLAMMATORY DISEASES (THE JOURNAL OF QAZVIN UNIVERSITY OF MEDICAL SCIENCES), -(26), 0-0. https://www.sid.ir/en/journal/ViewPaper.aspx?id=2500



Vancouver: Copy

MORTAZAVI S.R., JAFARI M., ABBASI E., DERAKHSHAN F.. EFFECTS OF AGING ON CHOLINERGIC AND ADRENERGIC SYSTEMS RESPONSIVENESS OF RAT ISOLATED ATRIUM. JOURNAL OF INFLAMMATORY DISEASES (THE JOURNAL OF QAZVIN UNIVERSITY OF MEDICAL SCIENCES). 2003 [cited 2021May15];-(26):0-0. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=2500



IEEE: Copy

MORTAZAVI, S., JAFARI, M., ABBASI, E., DERAKHSHAN, F., 2003. EFFECTS OF AGING ON CHOLINERGIC AND ADRENERGIC SYSTEMS RESPONSIVENESS OF RAT ISOLATED ATRIUM. JOURNAL OF INFLAMMATORY DISEASES (THE JOURNAL OF QAZVIN UNIVERSITY OF MEDICAL SCIENCES), [online] -(26), pp.0-0. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=2500.



 
 
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