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Paper Information

Journal:   THE JOURNAL OF QAZVIN UNIVERSITY OF MEDICAL SCIENCES   Spring 2003 , Volume - , Number 25; Page(s) 47 To 47.
 
Paper: 

ANTIBODY RESPONSE TO HEPATITIS B VACCINATION IN HEMODIALYTIC PATIENTS

 
 
Author(s):  SHARIFI M., TALEBI TAHER M., SADEGHI M.
 
* 
 
Abstract: 
Background: Immune deficiency in hemodialytic and uremic patients decreases antibody response after hepatitis B (HB) vaccination. Acceptable response among these patients is an antibody level above 100 mIU/ml.
Objective: To determine antibody response in hemodialytic patients after hepatitis B vaccination.
Methods: A cross sectional descriptive study with census sampling was implemented on hemodialytic patients in Bou-Ali Sina teaching hospital of Qazvin in 2000. Eliminating HBsAg positive and unvaccinated patients, final population was reduced from 70 to 63. Serum samples were tested by ELISA.
Findings: Antibody level in 16 patients (25.4%) was undetectable and in overall 37 patients (58.7%) there was no protective antibody level (100 mIU/ml) despite vaccination. Response in female was 51.5% and in male was 30%.
Conclusion: With regard to the risk of hepatitis B, completion of vaccination and quantitative test to determine the antibody response for hemodialytic patients is necessary.
 
Keyword(s):  HEMODIALYSIS, ANTIBODY RESPONSE, HEPATITIS B, VACCINE
 
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