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Paper Information

Journal:   CELL JOURNAL (YAKHTEH)   Winter 2004 , Volume 5 , Number 20; Page(s) 140 To 145.
 
Paper: 

THE MORPHOLOGICAL EXPRESSION OF ENDOMETRIAL PINOPODES DURING IMPLANTATION IN MICE AFTER OVAIAN STIMULATION AND PROGESTERONE INJECTION

 
 
Author(s):  EMADI M.*, SALEHNIA M.
 
* ANATOMY DEPARTMET, TARBIAT MODARRES UNIVERSITY OF MEDICAL SCIECES, TEHRAN, IRAN
 
Abstract: 

Introduction: The aim of this study was to evaluate the expression of pinopodes as an implantation marker after ovarian hyperstimulation and progesterone injection using scanning electron microscope studies.
Material and Methods: Three groups of NMRI adult female mice were used in the experiment. The control group (Group A) was untreated pseudopregnant mice. Group B mice were made pseudopregnant after superovulation treatment with hMG. Group C mice were treated the same as Group B and then received progesterone daily from day 1 of pseudo pregnancy. Animals were sacrificed by cervical dislocation 3.5 and 4.5 days after hCG injection. Tissues were obtained from the middle 1/3 part of uterine horns and processed for scanning electron microscopic studies.
Results: In the control group there were some pinopodes at 3.5 days of pseudopregnancy and the apical surface of all cells expressed these projections on day four. In the hyperstimulated group without progesterone injection no pinopodes were seen 3.5 days after hCG injection and some appeared on day 4. In the hyperstimulated and progesterone - injected group well developed pinopodes were expressed 3.5 days after stimulation and they became much smaller on day 4 after hCG injection.
Conclusion: The results showed that the life span of pinopodes is short and changeable during hyperstimulation and that progesterone causes premature expression of the pinopodes, suggesting that the implantation after ovarian stimulation might depend upon the timing of the pinopodes expression.

 
Keyword(s): OVARIAN STIMULATION, PINOPODE, PROGESTERONE, SCANNING ELECTRON MICROSCOPY
 
References: 
 
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