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Paper Information

Journal:   JOURNAL OF VETERINARY RESEARCH   2011 , Volume 66 , Number 1; Page(s) 23 To 30.
 
Paper: 

ASSOCIATION BETWEEN AMINO ACID SEQUENCES IN PEPTIDE BINDING REGION (BOLA-DRB3) AND SUSCEPTIBILITY OR RESISTANCE TO CALF DIARRHEA

 
 
Author(s):  NIKBAKHT BOROUJENI GH.R.*, TADJBAKHSH H., MOKHBER DEZFOULI M.R., ZAHRAEI SALEHI TAGHI, RABBANI M., GHARIBI D., EMAM M., ASSADIAN F., KHORMALI M.
 
* DEPARTMENT OF MICROBIOLOGY AND IMMUNOLOGY, FACULTY OF VETERINARY MEDICINE, UNIVERSITY OF TEHRAN, TEHRAN, IRAN
 
Abstract: 

The major histocompatibility complex genes (mhc) encode MHC I and II molecules which present peptide fragments to Tcells. Therefore these polymorphic molecules critically influence susceptibility to infectious diseases. At present study potential relationship between amino acid sequences in the antigen binding groove of different BoLA-DRB3 alleles and susceptibility or resistance to calf diarrhea was investigated. Twelve different DRB3 alleles were found among 171 calves (84 diarrheic and 87 healthy) analyesd by PCR-RFLP method. Amino acid sequences of the encoded peptide binding region were compared. 26 polymorphic positions were detected in this region. A significant association (p< 0.05) was shown between occurrence of diarrhea and the presence of glutamic acid and tyrosine in pocket 4 and valine, glutamine and leucine in pocket 9 of peptide binding region. Thus it can be concluded that pockets 4 and 9 of the BoLA-DRB3 molecule would be involved in conferring susceptibility of calf to diarrhea.

 
Keyword(s): MHC, BOLA-DRB3, PCR-RFLP, CALF DIARRHEA, PEPTIDE BINDING REGION
 
 
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+ Click to Cite.
APA: Copy

NIKBAKHT BOROUJENI, G., & TADJBAKHSH, H., & MOKHBER DEZFOULI, M., & ZAHRAEI SALEHI, T., & RABBANI, M., & GHARIBI, D., & EMAM, M., & ASSADIAN, F., & KHORMALI, M. (2011). ASSOCIATION BETWEEN AMINO ACID SEQUENCES IN PEPTIDE BINDING REGION (BOLA-DRB3) AND SUSCEPTIBILITY OR RESISTANCE TO CALF DIARRHEA. JOURNAL OF VETERINARY RESEARCH, 66(1), 23-30. https://www.sid.ir/en/journal/ViewPaper.aspx?id=194530



Vancouver: Copy

NIKBAKHT BOROUJENI GH.R., TADJBAKHSH H., MOKHBER DEZFOULI M.R., ZAHRAEI SALEHI TAGHI, RABBANI M., GHARIBI D., EMAM M., ASSADIAN F., KHORMALI M.. ASSOCIATION BETWEEN AMINO ACID SEQUENCES IN PEPTIDE BINDING REGION (BOLA-DRB3) AND SUSCEPTIBILITY OR RESISTANCE TO CALF DIARRHEA. JOURNAL OF VETERINARY RESEARCH. 2011 [cited 2021July30];66(1):23-30. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=194530



IEEE: Copy

NIKBAKHT BOROUJENI, G., TADJBAKHSH, H., MOKHBER DEZFOULI, M., ZAHRAEI SALEHI, T., RABBANI, M., GHARIBI, D., EMAM, M., ASSADIAN, F., KHORMALI, M., 2011. ASSOCIATION BETWEEN AMINO ACID SEQUENCES IN PEPTIDE BINDING REGION (BOLA-DRB3) AND SUSCEPTIBILITY OR RESISTANCE TO CALF DIARRHEA. JOURNAL OF VETERINARY RESEARCH, [online] 66(1), pp.23-30. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=194530.



 
 
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