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Paper Information

Journal:   IRANIAN JOURNAL OF PSYCHIATRY AND CLINICAL PSYCHOLOGY   FALL 2010 , Volume 16 , Number 3 (62); Page(s) 321 To 322.
 
Paper: 

DOUBLE BLIND CROSS-OVER PLACEBO-CONTROLLED CLINICAL TRIAL OF ADJUNCTION OF DONEPEZIL TO ATYPICAL ANTIPSYCHOTIC DRUGS OF SCHIZOPHRENIC PATIENTS FOR RECOVERY OF POSITIVE, NEGATIVE AND GENERAL PSYCHOPATOLOGY

 
 
Author(s):  TAYEBI A.*, FADAIEE F., NIKNAMI Z.
 
* 
 
Abstract: 

Objectives: The main effects of antipsychotics are on the positive symptoms of schizophrenia. These drugs minimized severity of delusions and hallucinations or inhibited them‚ they decrease irritable mood‚ bizarre and aggressive behaviors of schizophrenic patients. Most of these drugs have little effects on withdrawal‚ apathy or other negative symptoms of schizophrenic patients. Therefore searching for other methods of treatment of schizophrenic patients is necessary.
Method: We conducted at 14 wk double blind‚ crossed – over trial of Donepezil, at doses of 5 mg /day or placebo for 6 weeks‚ Added to ongoing atypical antipsychotic in 24 stable schizophrenic in–patients who were diagnosed according to DSM-IV-TR criteria and had been on a stable dose of a high– potency atypical antipsychotic for a minimum period of three months. After a two week wash out period they crossed over to the alternate condition for additional 6 weeks. At baseline‚ 6 and 14 week‚ patients were evaluated with the Positive and Negative Syndrome Scale (PANSS(.
Results: Negative subscale of PANSS improved by Donepezil in group 2. It was statistically significant (p> 0.47). Donepezil increased numerically the positive sub-scale of PANSS in both group but it was not significant statistically.
Conclusion: Statistically significant improvement in PANSS results can be rational for adding cholinesterase inhibitors to antipsychotics in schizophrenia. Larger trials with sufficient duration are needed to resolve this issue.

 
Keyword(s): DONEPEZIL, SCHIZOPHRENIA, ANTIPSYCHOTIC
 
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