Paper Information

Journal:   SCIENTIFIC-RESEARCH IRANIAN VETERINARY JOURNAL   SUMMER 2010 , Volume 6 , Number 2 (27); Page(s) 66 To 72.
 
Paper: 

A CASE REPORT OF MODERATELY DIFFERENTIATED SERTOLI ‍CELL TUMOR IN DOG (CASE REPORT)

 
Author(s):  ASHRAFIHELAN J.*, HEJAZI M., BAREKATEIN H., MASOUDIFARD M., JAFARI N.
 
* DEPARTMENT OF PATHOBIOLOGY, FACULTY OF VETERINARY MEDICINE, UNIVERSITY OF TABRIZ, IRAN
 
Abstract: 
A 10-year-old intact male mixed Spitz was referred to a Small Animal Hospital, Faculty of Veterinary Medicine, University of Tehran with a history of lameness. Clinical examination revealed alopecia, gynaecomastia and left unilateral cryptorchidism. The left testis was undescended and a large and firm mass was located at the left inguinal region. The CBC indicated mild hypochromic anemia, thrombocytopenia and neutrophilic leukocytosis. Radiographic examination showed a mass with soft tissue density. Ultrasonography revealed an oval encapsulated echogenic mass. After surgical resection, a firm, ovoid and slightly lobulated mass with 7×8×9.5 cm in size was seen. The cut surface was homogenous and cream in colour. Microscopically, the tumor consisted of masses of neoplastic cells with large, hyperchromatic and pleomorphic nuclei and a large nucleoli and poorly defined eosinophilic cytoplasm with fine lipid droplets. The neoplastic cells were arranged in sheet of cells and show little differentiation and tendency to palisade. In some areas, the cells relatively resembled sertoli cells and were rather elongate with foamy acidophilic cytoplasm and elongated nuclei. In this area, the stromal tissues were arranged to provide a pseudotubular pattern in which the neoplastic cells tend to palisade. On the basis of clinical and pathologic findings, the mass was diagnosed as a moderately differentiated Sertoli Cell Tumor.
 
Keyword(s): SERTOLI CELL, TUMOR, MODERATELY DIFFERENTIATED, INGUINAL, DOG
 
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