Paper Information

Journal:   IRANIAN JOURNAL OF PSYCHIATRY AND CLINICAL PSYCHOLOGY   FALL 2010 , Volume 16 , Number 3 (62); Page(s) 281 To 281.
 
Paper: 

A STUDY OF THE FREQUENCIES OF SEIZURES DUE TO TRAMADOL CONSUMPTION IN REFEREES TO KERMANSHAH FARABI HOSPITAL

 
 
Author(s):  TATARI F.*, AFSHARI D., ABDOLI N., REZAII MANSOUR, ROSTAMI MOHSEN
 
* KERMANSHAH UNIVERSITY OF MEDICA SCIENCES
 
Abstract: 

Objectives: Tramadol as a centrally acting, opioid-like analgesic with serotonin reuptake inhibition properties is one of the most prescribed analgesics in the world. After a short time since its introduction there were some reports of tramadol abuse and then after tramadol-induced seizures. In this study we assessed the frequencies of seizure due to tramadol.
Method: This descriptive study was conducted during September 2008 to 2009. All the referees to Kermanshah Farabi Hospital who consumed tramadol were interviewed. The demographic characteristics along with the duration and dosage of tramadol, and history of seizure after uphold by neurologist were recorded. The data were analyzed by SPSS software version 11.5.
Results: There were 520 referees (93.7% male and 6.3% female). 8.8% were illiterate, 31.7% high school, 38.3% holder of diploma, and 21.2% well educated. 13.5% were employed, 16.1% student, 25.8% unemployed, and 34.8% had other jobs. 60 participants (11.5%) had seizure during consumption, and 113 (21.7%) after discontinuation. The the mean age for seizure was 32.5 year old for those with seizure during consumption and 16.7 year old for the other group. The average of the dosage resulting to seizure was about 650 mg, although it was seen in a few cases in dosage 50mg to 2500mg.
Conclusion: Tramadol causes seizure even in therapeutic dosages; though the higher dosages are associated with higher risks. It seems that the prescription and administration of the medication needs a serious revision.

 
Keyword(s): KERMANSHAH FARABI HOSPITAL, TRAMADOL, SEIZURE
 
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