Paper Information

Journal:   IRANIAN JOURNAL OF PSYCHIATRY AND CLINICAL PSYCHOLOGY   FALL 2010 , Volume 16 , Number 3 (62); Page(s) 267 To 267.
 
Paper: 

RELAPSE RATE IN SHIZOPHRENIC PATIENTS TREATED WITH DEPOT ANTIPSYCHOTICS AND ATYPICAL AAGENTS

 
 
Author(s):  AHMADZADASL MASOUD*, AHMADKHANIHA H.R., BANIHASHEM SH.
 
* MENTAL HEALTH RESEARCH CENTER, TEHRAN PSYCHIATRIC INSTITUTE
 
Abstract: 

Objectives: The aim of the present study was comparing the relapse rate in schizophrenic patients treated with oral atypical agents (SDAs) with patients treated with depot preparation of conventional antipsychotics. Method: In this historical cohort study, Mean Relapse per Month (MRM) index, Duration between initiation of antipsychotic treatment and the first relapse episode, and the gap time between successive relapses were compared in 84 patients on SDAs (group1) and 81 patients on depot typical antipsychotics (group2). Results: Two groups were comparable regarding Mean±SD MRM index (0.033±0.004 in group1 and 0.044±0.05 in group 2 (P >0.5), the mean±SD duration of time between initiation of maintenance treatment and first relapse (15.5+13.67 months in group 1 and 16.40±15.31 months in group 2, P>0.876). Conclusion: Oral taken atypical antipsychotics are shown to be able to keep the duration of remission periods between successive relapses more prolonged, compared to depot conventional preparations. This could be added to their other remarkable benefits especially if the patient is expected to experience multiple relapses.

 
Keyword(s): DEPOT TYPICAL ANTIPSYCHOTICS, RELAPSE, SCHIZOPHRENIA
 
References: 
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