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Paper Information

Journal:   JOURNAL OF LARGE ANIMAL CLINICAL SCIENCE RESEARCH (JOURNAL OF VETERINARY MEDICINE)   2010 , Volume 4 , Number 12; Page(s) 75 To 79.
 
Paper: 

STUDY OF THE EFFECT OF CARBAMAZEPIN ORALLY ADMINISTRATION ON ELECTROCARDIOGRAM CHANGES (LEAD II) IN CATS

 
 
Author(s):  NESHAT GHARAMALEKY M.*, KHAYAT NOURI M.H., POURSHABAN M.
 
* DEPARTEMENT OF CLINICAL SCIENCES, VETERINARY FACULTY, ISLAMIC AZAD UNIVERSITY, TABRIZ, BRANCH, IRAN
 
Abstract: 
Carbamazepin is a tri-cyclic agent that is used for treatment of seizure in animals.
Most physicians and veterinarians use this drug to control tonic-colonic generalized seizures. Also, it has cardio toxic and idiosyncratic adverse reactions in human.
Some reports indicate carbamazepin induce sinoatrial and atrioventriclar dysfunction. Although carbamazepin is very useful in both human and animals, there is no existing previous survey studying electrocardiogram effects of carbamazepin in cats. So, we decided to study the cardiac effect of this drug in cats.
We gathered 8 Domestic short haired male cats, and examined them for ruling out of any cardiac or other systems dysfunction. Then, cats were administered with 25mg carbamazepin, and their electrocardiograms in lead II were recorded before drug administration and 4 and 8 hours after. Analyzing data with t test, we didn't find any significant changes in electro cardiogram parameters and no potential arrhythmic signs were detected after carbamazepin administration. We concluded that this dose of carbamazepin can be safe for cat because no arrythmogenic phenomenon wasn’t induced by this drug and it can be noted that carbamazepin is very useful in modulating animal tempers.
 
Keyword(s): CARBAMAZEPIN, CAT, ECG
 
References: 
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