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Paper Information

Journal:   JOURNAL OF APPLIED RESEARCHES IN CHEMISTRY (JARC)   SPRING 2009 , Volume 3 , Number 9; Page(s) 15 To 20.
 
Paper: 

SIMULTANEOUS QUANTITATION OF THEOPHYLLINE AND GUAIFENESIN IN SYRUP BY CWT AND DERIVATIVE SPECTROPHOTOMETRY FOR QUALITY CONTROL PURPOSES

 
 
Author(s):  SOHRABI MAHMOUD REZA, ALAEDDINI ENSIEH*, JAVANBAKHT MEHRAN, SAREBAN MONIREH, MARANDI PARI
 
* DEPARTMENT OF CHEMISTRY, ISLAMIC AZAD UNIVERSITY, NORTH TEHRAN BRANCH, TEHRAN, IRAN
 
Abstract: 

The aim of the present work was to develop a simple and rapid method for determination of Theophylline (THP) and Guaifenesin (GU) in syrup. Simultaneous analysis theophylline and guaifenesin was carried out by continuous wavelet transform (CWT) and derivative spectrophotometry (DS) without involving any preparation operations like chemical separation step or masking. THP, a member of xanthine based alkaloids, which relaxes smooth muscles and relieves bronco spasm, has a stimulant effect on respiration. GU, a mucolytic agent, is used as an expectorant. The use of the mixture of THP and GU in the symptomatic treatment of bronchial asthma and other broncho spastic conditions is well established in pharmaceutical formulations. In the CWT method, the determination was performed at 270.2 nm for THP and at 224.4 nm for GU (for wavelet family coif 5, a=300). In the first-derivative spectrophotometry determination of THP and GU was realized by measurements of amplitudes of derivative spectra corresponding to zero-crossing points of THP and GU at 305 and 242.4 nm, respectively. The proposed procedures were validated by using various synthetic mixtures with high percentage of recovery and good precision. Mean recovery values were found 99.90% and 101.2% for CWT calibration method and 96% and 98% for derivative spectrophotometry, respectively for determination of THP and GU in synthetic mixtures. Also good agreement between the results obtained using the two procedures was found, which agreed also with the product label.

 
Keyword(s): THEOPHYLLINE, GUAIFENESIN, CALIBRATION, DERIVATIVE SPECTROPHOTOMETRY, CONTINUOUS WAVELET TRANSFORM
 
 
References: 
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Citations: 
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+ Click to Cite.
APA: Copy

SOHRABI, M., & ALAEDDINI, E., & JAVANBAKHT, M., & SAREBAN, M., & MARANDI, P. (2009). SIMULTANEOUS QUANTITATION OF THEOPHYLLINE AND GUAIFENESIN IN SYRUP BY CWT AND DERIVATIVE SPECTROPHOTOMETRY FOR QUALITY CONTROL PURPOSES. JOURNAL OF APPLIED RESEARCHES IN CHEMISTRY (JARC), 3(9), 15-20. https://www.sid.ir/en/journal/ViewPaper.aspx?id=193899



Vancouver: Copy

SOHRABI MAHMOUD REZA, ALAEDDINI ENSIEH, JAVANBAKHT MEHRAN, SAREBAN MONIREH, MARANDI PARI. SIMULTANEOUS QUANTITATION OF THEOPHYLLINE AND GUAIFENESIN IN SYRUP BY CWT AND DERIVATIVE SPECTROPHOTOMETRY FOR QUALITY CONTROL PURPOSES. JOURNAL OF APPLIED RESEARCHES IN CHEMISTRY (JARC). 2009 [cited 2021July30];3(9):15-20. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=193899



IEEE: Copy

SOHRABI, M., ALAEDDINI, E., JAVANBAKHT, M., SAREBAN, M., MARANDI, P., 2009. SIMULTANEOUS QUANTITATION OF THEOPHYLLINE AND GUAIFENESIN IN SYRUP BY CWT AND DERIVATIVE SPECTROPHOTOMETRY FOR QUALITY CONTROL PURPOSES. JOURNAL OF APPLIED RESEARCHES IN CHEMISTRY (JARC), [online] 3(9), pp.15-20. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=193899.



 
 
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