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Paper Information

Journal:   JOURNAL OF REPRODUCTION AND INFERTILITY   JANUARY-MARCH 2011 , Volume 12 , Number 1 (46); Page(s) 3 To 7.
 
Paper: 

EFFECTS OF KAMDHENU ARK AND ACTIVE IMMUNIZATION BY GONADOTROPIN RELEASING HORMONE CONJUGATE (GNRH-BSA) ON GONADOSOMATIC INDICES (GSI) AND SPERM PARAMETERS IN MALE MUS MUSCULUS

 
 
Author(s):  GANAIE JAVID AHMAD, GAUTAM VARSHA, SHRIVASTAVA VINOY KUMAR*
 
* VINOY KUMAR SHRIVASTAVA, ENDOCRINOLOGY LABORATORY, DEPARTMENT OF BIOSCIENCE, BARKATULLAH UNIVERSITY, BHOPAL (M.P.) INDIA
 
Abstract: 

Background: Active immunization against GnRH decreases the secretion of gonado-tropins and causes cessation of gonadal function, thereby, inducing infertility. Based on the immunoenhancing activity of Kamdhenu ark (distilled cow urine), this study was performed to evaluate its effects on the gonadosomatic indices (GSI) and sperm parameters in male mice receiving a GnRH contraceptive vaccine.
Methods: Sixty adult male mice of Parke’s strain were divided into three groups of twenty. Group I served as the controls, while group II was immunized by GnRH-BSA conjugate (50/0.2/35 µg/ml/g BW) by four intraperitoneal injections at different inter-vals on days 1, 30, 60 and 90. However, group III was supplemented daily by oral Kamdhenu ark (100 ppm) along with GnRH-BSA immunizations. The animals were sacrificed after 30, 60, 90 and 120 days and their testis and epididymis were dissected outweighed and semen analysis was performed
.
Results: GSI values, sperm motility, sperm count and sperm morphology in male Mus musculus were decreased significantly in all the experimental groups as compared to the control group (p<0.01). Kamdhenu ark significantly enhanced the effect of GnRH vaccine on the aforesaid parameters especially in 90 and 120 days treated groups (p<0.05).

Conclusion: The changes witnessed in sperm parameters suggested that the GnRH-BSA immunization suppressed the activities of gonadotropins and testosterone direct-ly through hypothalamo-hypophysial-gonadal axis and indirectly by acting on the testes which may modulate the sperm morphology, sperm count and motility. How-ever, Kamdhenu ark seems to have enhanced these effects because of its immune-modulatory properties too
.

 
Keyword(s): GNRH-BSA, GONADOSOMATIC INDICES (GSI), IMMUNIZATION, KAMDHENU ARK, MUS MUSCULUS, SPERM PARAMETERS
 
 
References: 
 
Citations: 
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APA: Copy

GANAIE, J., & GAUTAM, V., & SHRIVASTAVA, V. (2011). EFFECTS OF KAMDHENU ARK AND ACTIVE IMMUNIZATION BY GONADOTROPIN RELEASING HORMONE CONJUGATE (GNRH-BSA) ON GONADOSOMATIC INDICES (GSI) AND SPERM PARAMETERS IN MALE MUS MUSCULUS. JOURNAL OF REPRODUCTION AND INFERTILITY, 12(1 (46)), 3-7. https://www.sid.ir/en/journal/ViewPaper.aspx?id=193881



Vancouver: Copy

GANAIE JAVID AHMAD, GAUTAM VARSHA, SHRIVASTAVA VINOY KUMAR. EFFECTS OF KAMDHENU ARK AND ACTIVE IMMUNIZATION BY GONADOTROPIN RELEASING HORMONE CONJUGATE (GNRH-BSA) ON GONADOSOMATIC INDICES (GSI) AND SPERM PARAMETERS IN MALE MUS MUSCULUS. JOURNAL OF REPRODUCTION AND INFERTILITY. 2011 [cited 2021July28];12(1 (46)):3-7. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=193881



IEEE: Copy

GANAIE, J., GAUTAM, V., SHRIVASTAVA, V., 2011. EFFECTS OF KAMDHENU ARK AND ACTIVE IMMUNIZATION BY GONADOTROPIN RELEASING HORMONE CONJUGATE (GNRH-BSA) ON GONADOSOMATIC INDICES (GSI) AND SPERM PARAMETERS IN MALE MUS MUSCULUS. JOURNAL OF REPRODUCTION AND INFERTILITY, [online] 12(1 (46)), pp.3-7. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=193881.



 
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