Paper Information

Journal:   HEPATITIS MONTHLY   APRIL 2011 , Volume 11 , Number 4 (33); Page(s) 263 To 268.
 
Paper: 

RISK FACTORS OF HEPATITIS B VIRUS INFECTION IN TURKEY: A POPULATION-BASED, CASE-CONTROL STUDY

 
Author(s):  OZER ALI, YAKUPOGULLARI YUSUF*, BEYTUR ALI, BEYTUR LEYLA, KOROGLU MEHMET, SALMAN FEYZA, AYDOGAN FISUN
 
* INONU UNIVERSITY MEDICAL SCHOOL, CLINIC MICROBIOLOGY DEPARTMENT, MALATYA, TURKEY
 
Abstract: 

Background: Although the World Health Organization (WHO) classifies Turkey as a country with a moderate-high prevalence of hepatitis B virus (HBV) infection, there is little data on HBV transmission in this country.
Objectives: To identify risk factors for HBV infection, we performed a retrospective case-control study between January 2007 and December 2009.
Patients and Methods: Acute HBV patients and population controls were selected, and data from these groups were analyzed by logistic regression. method.
Results: The study included 129 patients with acute HBV infection and 219 controls. Hemodialysis (OR: 8.2, 95% CI: 4.17-16.61, p<0.05), having an HBsAg (+) spouse (OR: 4.3, 95% CI: 2.17-8.53, p<0.05), living with an HBsAg (+) parent (s) (OR: 3.25, 95% CI: 1.73-6.12, p<0.05), and being male (OR: 1.34, 95% CI: 0.82-2.21, p<0.05) were independent risk factors that were potentially associated with HBV infection. More than one-third of female patients had a significantly higher risk (34.5% vs.13.5%, p<0.05) of acquiring HBV from their sexual partners. Hemodialysis was the most frequent risk factor (46.9% vs.20%, x²=10.45, p<0.05) for patients aged over 31 years, and living with HBsAg (+) parents was a significantly higher risk factor (28.8% vs.10.2%, x²=6.15, p<0.05) that is more likely to lead to HBVin patients aged under 30 years.
Conclusions: This study suggests that persons in Turkey who undergo hemodialysis are at high risk for acquiring HBV. Having an HBsAg (+) spouse (sexual transmission) or living with HBsAg (+) parents (household transmission) are significant risk factors for HBV transmission. Vaccination appears to be better preventive method against the spread of HBV.

 
Keyword(s): HEPATITIS B VIRUS, TRANSMISSION, RISK FACTOR
 
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