Paper Information

Journal:   BIOLOGY JOURNAL   SPRING 2009 , Volume 4 , Number 1; Page(s) 9 To 20.
 
Paper: 

THE HYPOLIPIDEMIC EFFECTS OF ANETHUM IN NORMAL AND STREPTOZOCIN- INDUCED DIABETIC RATS

 
 
Author(s):  PIRI MORTEZA*, ORYAN SHAHRBANOU, SHAHIN MARYAM SADAT, NASEHI MOHAMMAD
 
* DEPARTMENT OF BIOLOGY, FACULTY OF BASIC SCIENCES, AZAD UNIVERSITY, ARDABILE BRANCH, ARDABILE, IRAN
 
Abstract: 

Objective: In diabetic patient, dyslipidemia caused an increase in the risk of cardiovascular disease. The search for a new drug with the potential of reduction or regulation of serum lipid and lipoproteins has received wide attention in recent years. The present study investigated the hypolipidemic effects of Anethum in normal and streptozocin- induced diabetic rats.
Method: Diabetes induced by streptozocin (60 mg/kg, i.p) injection. Then normal and diabetic rats treatment by oral administration of 50, 100 and 200m g/kg body wt. of Anethum for 21 days after which blood samples were collected following an over-night fast and the serum was separated. Then total triglyceride, total cholesterol and HDL-C in each serum sample were determined enzymatically using commercial Kits and serum LDL-C levels were derived using the Friedewald formula.
Results: In normal rats, Anethum significantly decreased triglyceride and LDL-C and increased HDL-C but could not affect blood total cholesterol level. Results also show that Anethum has not antilipidemic effect on diabetic rats. Also Anethum decrease body weight in normal and diabetic rats.
Conclusion: These results showed that Anethum has a strong antilipidemic effect in normal rats, but is not an effective drug for lipid lowering in Streptozocin- induced diabetic rats.

 
Keyword(s): ANETHUM, STREPTOZOCIN- INDUCED DIABETES, TRIGLYCERIDE, CHOLESTEROL, LIPOPROTEINS
 
References: 
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