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Paper Information

Journal:   TANAFFOS   FALL 2010 , Volume 9 , Number 4; Page(s) 22 To 27.
 
Paper: 

IFN-γ+874 AND IL-4 -590 POLYMORPHISMS AND ASTHMA SUSCEPTIBILITY IN NORTH WEST OF IRAN

 
 
Author(s):  ABDI RAD I.*, BAGHERI MORTEZA, RAHIMIRAD M.H., MORADI Z.
 
* CELLULAR AND MOLECULAR RESEARCH CENTER, URMIA UNIVERSITY OF MEDICAL SCIENCES, URMIA, IRAN
 
Abstract: 

Background: Recent studies have documented an association between some cytokines’ gene polymorphisms and chronic inflammation of the respiratory tract which leads to asthma susceptibility. This study was conducted to investigate if there were any differences in IFN-g +874 (A/T) and IL-4 -590 (C/T) single nucleotide variations in asthmatic patients compared to normal controls among West Azerbaijani population.
Materials and Methods: IFN-
g +874 (A/T) and IL-4 -590 (C/T) polymorphisms were amplified by ASO-PCR and RFLP-PCR from genomic DNA of 173 individuals including 64 asthmatic patients and 109 control subjects from West Azerbaijani population.
Results: The allele or genotype frequencies of IFN-
g +874 A/T in patients were not different from those of controls (p>0.05). The differences between allelic or genotypic frequencies of IL-4 -590 C/T in patients and controls were not statistically significant (p>0.05).
Conclusion: These findings showed that IL-4 -590 (C/T) and IFN-
g +874 (A/T) polymorphisms were not associated with asthma susceptibility.

 
Keyword(s): POLYMORPHISM, ASTHMA, INTERFERON- γ (IFN-γ), INTERLEUKIN-4 (IL-4)
 
 
References: 
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Citations: 
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+ Click to Cite.
APA: Copy

ABDI RAD, I., & BAGHERI, M., & RAHIMIRAD, M., & MORADI, Z. (2010). IFN-γ+874 AND IL-4 -590 POLYMORPHISMS AND ASTHMA SUSCEPTIBILITY IN NORTH WEST OF IRAN. TANAFFOS, 9(4), 22-27. https://www.sid.ir/en/journal/ViewPaper.aspx?id=193309



Vancouver: Copy

ABDI RAD I., BAGHERI MORTEZA, RAHIMIRAD M.H., MORADI Z.. IFN-γ+874 AND IL-4 -590 POLYMORPHISMS AND ASTHMA SUSCEPTIBILITY IN NORTH WEST OF IRAN. TANAFFOS. 2010 [cited 2021July30];9(4):22-27. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=193309



IEEE: Copy

ABDI RAD, I., BAGHERI, M., RAHIMIRAD, M., MORADI, Z., 2010. IFN-γ+874 AND IL-4 -590 POLYMORPHISMS AND ASTHMA SUSCEPTIBILITY IN NORTH WEST OF IRAN. TANAFFOS, [online] 9(4), pp.22-27. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=193309.



 
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