Paper Information

Journal:   VETERINARY CLINICAL PATHOLOGY (VETERINARY JOURNAL TABRIZ)   FALL 2009 , Volume 3 , Number 3 (11); Page(s) 591 To 599.
 
Paper: 

THE EFFECT OF INTRAVENOUS INJECTION OF GHRELIN ON THE MEAN PLASMA CONCENTRATIONS OF INSULIN IN IMMATURE CAMELS FED DIFFERENT LEVELS OF THEIR ENERGY REQUIREMENTS

 
 
Author(s):  RASHEDI R.*, KHAZALI H.
 
* SHAHID BEHESHTI UNIVERSITY, TEHRAN, IRAN
 
Abstract: 

Ghrelin is a peptide hormone secreted into the circulation from the stomach, but this peptide is also synthetized in a number of different body tissues including the brain and pancreas, suggesting both endocrine and paracrine effects. These include: stimulation of GH and ACTH secretion, an increase in appetite and diabetogenic effect on carbohydrate metabolism. Furthermore, ghrelin is the natural ligand of the growth hormone secretagogue receptor (GHS-R). Ghrelin and its mRNA as well as GH secretagogue receptor mRNAs are expressed in the pancreas and islet cells and regulates insulin release and glucose metabolism, but because the effect of ghrelin on insulin secretion before puberty in semiruminant animals has never been examined,   therefore the purpose of the present research was to determine the effect of ghrelin on insulin secretion before puberty in camels. In this investigation 12 camels were randomly divided into two groups. Animals in each group were fed either 50% or 100% energy content in diet for 2 weeks. After 2 weeks camels received 8 μg ghrelin/kg body weights via their jugular vein for 4 days. Blood samples were collected from the jugular vein of all animals before, during (30 minutes after injection of ghrelin) and after the intervention for 4 continuous days and plasma insulin concentrations determined by RIA. Data obtained were analyzed by repeated measures –ANOVA and paired t-Test. p<0.05 were considered statistically significant. The results of this experiment indicated that the injection of ghrelin significantly decreased the mean plasma concentrations of insulin in pre pubertal camels receiving 50% and 100% dietary energy and there was no significant difference between the two diets regarling this effect.

 
Keyword(s): GHRELIN, INSULIN, IMMATURE CAMEL
 
References: 
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