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Paper Information

Journal:   BIOLOGY JOURNAL   WINTER 2010 , Volume 4 , Number 4; Page(s) 53 To 60.
 
Paper: 

THE EFFECT OF TESTOSTERONE HORMONE ON THE NEWBORN MOUSE FEMORAL SKELETAL MUSCLE IN VITRO

 
 
Author(s):  YAGHMAEI P., PARIVAR K., HAYATI RODBARI N., ZAREI Z.
 
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Abstract: 

Testosterone is secreted by testis Leydig cells has an important role in increasing muscle mass and the diameter of bone and function of the brain.
Objective: In this study the effect of testosterone hormone was investigated in in vitro conditions on newborn 10-days old NMRI mice thigh’s muscle.
For this purpose, newborn mice thigh s skeletal muscle of male and female with 1x1 mm dimensions was removed and on appropriate organ culture medium. tight muscle samples were exposed to testosterone hormone with doses of 1, 5, 20, and 500 micro liters in experimental group of 1, 2, 3 and 4 respectively the culture dishes, were placed in a co2 incubator with temperature 37oC for 3 days. Histological sections for microscopic studies of the samples were carried out. for evaluations of the effects of implemented testosterone hormone, nuclear diameter, the diameter of muscle fiber, and the number of muscle fiber nuclei were measured and compared with control samples.
Results: Microscopic studies showed a significant increase in the diameter of muscle fiber and the number of muscle fiber nuclei in the experimental groups compared with control samples. (P<0.05, P<0.01, P<0.001).

 
Keyword(s): TESTOSTERONE HORMONE, NMRI MICE, ORGAN CULTURE, SKELETAL MUSCLE
 
References: 
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