Due to complexity of Zinc metabolism in the body, there is much interest to study this element. Every phase of growth and development requires Zinc. Zinc deficiency leads to many complications including reproduction and fertility disorders, weakness of the immune system and occurrence of secondary infections. In this study, blood samples were obtained from the jugular vein of 200 apparently healthy sheep of Miandoab province using venoject tubes in each season of the year (a total of 800 samples) following age and gender determination. Based on the one-way analysis of variance, there was a significant difference (p<0.01) in serumic levels of Zinc and alkaline phosophatase between difference seasons indicating severe reduction of Zinc levels and increase in Alkalin phosophatase levels during the winter which could be due to consumption of hand fed dried forage containing dust and soil. Also in this study, there was a significant difference (p<0.01) in serumic levels of Zinc and Alkalin phosphatase between different ages of the animals. There was a significant difference in serumic levels of Zinc and Alkalin phosphatase between male and female sheep based on t-Test (p<0.01).