Paper Information

Journal:   JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES   MARCH-APRIL 2010 , Volume 18 , Number 1 (69); Page(s) 17 To 23.
 
Paper:  EFFECT OF CONSUMPTION OF TRIBULUS TERRESTRIS ON SERUM GLUCOSE AND LIPID LEVELS IN DIABETIC RATS
 
Author(s):  ROGHANI M., BALUCHNEJADMOJARAD TOURANDOKHT, ANDALIBI N., ANSARI F., SHARAYELI M.
 
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Abstract: 

Introduction: The effect of Tribulus terrestris (TT) on serum glucose and lipid levels was investigated in an experimental model of diabetes mellitus in rats.
Methods: Female Wistar rats were divided into control, TT-treated control, diabetic, glibenclamide-treated, and TT-treated diabetic groups. For induction of diabetes, streptozotcin (STZ) was administered (60 mg/Kg). Meanwhile, TT-treated groups received TT mixed with standard pelleted food at a weight ratio of 6.25% for 6 weeks. Serum glucose and lipid levels were determined before the study and at the 3rd and 4th week after the study.
Results: Serum glucose was significantly lower in TT-treated diabetic rats at 3rd and 6th weeks as compared to untreated diabetics (p<0.01 and p<0.005, respectively). In addition, serum total cholesterol, triglyceride, and LDL-cholesterol showed a significant reduction in TT-treated diabetic rats as compared to untreated diabetics (p<0.05). On the other hand, HDL-cholesterol level did not change significantly in TT-treated diabetic group as compared to untreated diabetic group. Conclusions: Oral administration of TT has a significant hypoglycemic effect and in long term leads to appropriate changes in serum LDL-cholesterol, total cholesterol, and triglyceride levels, but does not affect HDL-cholesterol levels in diabetic rats.

 
Keyword(s): TRIBULUS TERRESTRIS, DIABETES MELLITUS, GLUCOSE, LIPIDS
 
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