Paper Information

Journal:   JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS)   JANUARY 2011 , Volume 16 , Number 1; Page(s) 94 To 97.
 
Paper: 

INTERLEUKIN-4 AND INTERFERON- γ LEVELS IN EPSTEIN-BARR VIRUS-ASSOCIATED INFECTIOUS MONONUCLEOSIS AND NASOPHARYNGEAL CARCINOMA

 
 
Author(s):  BUDIANI DYAH R., HARYANA SOFIA M., SOSROSENO WIHASKORO*
 
* SCHOOL OF DENTISTRY, AIMST UNIVERSITY, SEMELING, BEDONG, KEDAH, MALAYSIA
 
Abstract: 

BACKGROUND: Cytokines have been suggested to participate in the pathogenesis of infectious mononucleosis (IM) and nasopharyngeal carcinoma (NPC).
METHODS: Serum levels and gene expression of interleukin-4 (IL-4) and interferon-
g (IFN-g) were assessed by immunologic and PCR assays, respectively in patients with Epstein-Barr virus (EBV) -associated IM and NPC and EBV negative controls.
RESULTS: The serum levels of IFN-
g were elevated, but those of IL-4 were decreased in IM and NPC patients as compared with those of the control group (p < 0.05).
CONCLUSIONS: These results suggest that serum levels of IFN-
g may be predominant over those of IL-4 during the course of IM and NPC.

 
Keyword(s): INTERFERON-GAMMA, INTERLEUKIN-4, INFECTIOUS MONONUCLEOSIS, NASOPHARYNGEAL NEOPLASMS
 
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