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Paper Information

Journal:   IRANIAN QUARTERLY JOURNAL OF BREAST DISEASE   SUMMER 2009 , Volume 2 , Number 2 (5); Page(s) 7 To 13.
 
Paper: 

TAXANES BASED REGIMEN AS A RISK FACTOR FOR CHEMOTHERAPY INDUCED AMENORRHEA (CIA)

 
 
Author(s):  NAJAFI SAFA*, ESMAEELI DJAVID GHOLAMREZA, MEHRDAD NEDA, RAJAII ELAHE, ALAVI NASRINSADAT, OLFATBAKHSH ASEIH, NAJAFI MASOMEH, BAHRAMI ALIREZA, HEIDARI KAZEM
 
* IRANIAN CENTER FOR BREAST CANCER (ICBC), ACADEMIC CENTER FOR EDUCATION, CULTURE AND RESEARCH (ACECR), TEHRAN, IRAN
 
Abstract: 
Purpose: The objective of our study was so to show the impact of different chemotherapy regimens on induction of amenorrhea (CIA) in premenopausal women with breast cancer at different 1 ages.
Method: This is a follow-up study in 226 premenopausal women with breast cancer, who received one of the three groups of chemotherapy regimens: Conventional (CMF), antracyclinebased, and anthracycline- Taxanes based. They were evaluated for incidence of CIA in the follow-up clinic of ICBC Iranain Center for Braest Cancer (ICBC). Statistical analysis using SPSS software was performed and logistic regression was used to determine the risk factors of CIA.
Results: From 226 patients with a median age of 40 yrs (26-56 yrs) who participated in this study, 154 patients (68.1%) were developed CIA, which in 101 patients (65.6%), CIA was established and never resumed. CIA was present in 52.5% of patients treated with conventional regimens (CMF), in 66.7% of patients treated with anthracyclines and in 78.7% of patients treated with anthracycline-taxan. So the frequency of CIA was significantly higher in Taxanes based chemotherapy group than the others (p=0.015).
Although a slightly superior incidence of CIA in patients with hormone-insensitive tumors (ER-and PR-) versus hormone-sensitive tumors (ER+/or PR+) treated with combination regimens was observed, no statistically significant difference was found (p=0.629). From all the risk factors that were evaluated, anthracycline-taxan based regimen (OR: 4.14.059, CI95%: 1.6 10.21.6-9.8) and age> 40 yrs (OR: 3.23.5, CI95%: 1.7-6.11.9-6.6) were the most important factors in developing CIA in the study.
Conclusion: The type of chemotherapy and age at the breast cancer diagnosis are the most important risk factors in CIA and Taxanes-based regimens induced more CIA than the other regimens.
 
Keyword(s): CHEMOTHERAPYINDUCED AMENORRHEA, TAXANES, BREAST CANCER
 
References: 
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