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Paper Information

Journal:   IRANIAN HEART JOURNAL (IHJ)   FALL 2010 , Volume 11 , Number 3; Page(s) 47 To 49.
 
Paper: 

EXERTIONAL DYSPNEA AND LEFT ATRIAL MASS

 
 
Author(s):  MOZAFFARI KAMBIZ*, YAZDANI BIUCKI FARZAD, OMRANI GHOLAMREZA, HASHEMI JAFAR, AMINI AHMAD
 
* SURGICAL PATHOLOGY LABORATORY, SHAHEED RAJAIE CARDIOVASCULAR, MEDICAL AND RESEARCH CENTER, MELLAT PARK, VALI ASR AVE., TEHRAN, IRAN
 
Abstract: 

We present a 56-year-old woman who came to the emergency department with an exertional dyspnea of recent onset. A transthoracic echocardiographic examination revealed two round masses in her left atrium with mild mitral stenosis and mild-to-moderate mitral valve regurgitation.
Her laboratory data were unremarkable except for a mild anemia. Surgical excision of the masses was performed, and two creamy-white fleshy tumors were removed. On cross section, they were solid and creamy-brown with gritty areas.
Histopathological examination showed extensive sheets of round to oval cells, and hemangiopericytoma-like patterns.
Also, multiple lobules of well-differentiated hyaline cartilage were present. An immunohistochemistry (IHC) panel revealed that the chondroid areas were reactive for S100 protein. The round cells expressed CD99 with focal positivity for NSE (neuron-specific enolase), but were negative for the following cytokeratin, CD34, factor VIII, actin, and desmin. Therefore, the cells were mesenchymal in origin with chondroid differentiation, and the final diagnosis was a mesenchymal chondrosarcoma.
A full-scale investigation into the source of the tumor was unrevealing. Shortly after her discharge from the hospital, she developed an embolic cerebrovascular accident.

 
Keyword(s): HEART TUMOR, SARCOMA, DYSPNEA
 
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