Paper Information

Journal:   IRANIAN JOURNAL OF DERMATOLOGY   WINTER 2010 , Volume 13 , Number 4 (54); Page(s) 122 To 127.
 
Paper: 

EVALUATION OF A NOVEL HERBAL FORMULATION IN THE TREATMENT OF ECZEMA WITH PSORALEA CORYLIFOLIA

 
 
Author(s):  GIDWANI BEENA*, ALASPURE RN, DURAGKAR NJ, SINGH VIJAY, RAO S.PRAKASH, SHUKLA S.S.
 
* SHARAD PAWAR COLLEGE OF PHARMACY, NAGPUR,MAHARASHTRA, INDIA
 
Abstract: 

Background: We studied the efficacy of an herbal semisolid formulation, prepared from hexane extract of seeds of Psoralea Corylifolia, which has anti-inflammatory and antimicrobial properties, in the treatment of eczema.
Methods: Extraction of seeds of Psoralea Corylifolia was done in Soxhlet apparatus using hexane as the solvent. Furthermore, Oil in Water (O/W) cream was formulated with a stearic acid base and was evaluated for various parameters like pH, viscosity, rheology, etc. This cream was then utilized for the treatment of eczema.
Results: The formulation was effective in treating eczema in this open clinical trial. Thirty patients suffering from eczema were treated for 1 month, out of whom twenty five completed the study. The patients recovered from their symptoms using the cream twice daily and were assessed every week for 1 month. It was observed that the symptoms score reduced at the end of 2 weeks onwards. At the end of the study, the symptom score for eczema reduced from 6.367
±1.098 to 0.333±0.279 for length of the lesion, from 1.333±0.994 to 0.165±0.087 for exudation rate, and from 2.567±0.504 to 0.165±0.132 for the rate of itching.
Conclusion: The plant Psoralea Corylifolia has been used in treatment of various skin disorders, and the present research concluded that this plant could be effectively used for the treatment of eczema.

 
Keyword(s): PSORALEA CORYLIFOLIA, SEMISOLID FORMULATION, ECZEMA, HERBAL MEDICINE
 
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