Paper Information

Journal:   JOURNAL OF ANIMAL BIOLOGY   FALL 2008 , Volume 1 , Number 1; Page(s) 57 To 67.
 
Paper: 

EFFECT OF CANNABINOIDERGIC DRUGS IN THE DORSAL HIPPOCAMPUS OF MORPHINE SENSITIZED RATS IN THE MEMORY FORMATION

 
 
Author(s):  NAVAYIYAN M., PAKPOR B., ZARIN DAST M., ORYAN SH.
 
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Abstract: 

In present study, the effects of intra-dorsal hippocampal (intra-CA1) injection of cannabinoid receptor agents on memory formation have been investigated in 3-days morphine-treated rats. Method: Passive avoidance task of memory has been used to examine for retrieval of memory formation, 24 h after training. morphine was injected subcutaneously (S.C.), once daily for 3-days followed by 5 days free of the morphine before training.
Results: Post-training intra-CA1 administration of cannabinoid receptor agonist, WIN55, 212-2 (0.25 and 0.5
mg/rat) and CB1 receptor antagonist, AM251 (25 and 50 ng/rat, intra–CA1) decreased memory retrieval. Administration of AM251 (25, 50 and 100 ng/rat, intra - CA1), 2 min before injection of effective dose of WIN55, 212-2 (0.5 mg/rat) decreased the response induced by WIN55, 212-2. Repeated administration of different doses of morphine (2.5, 5 and 10 mg /kg) for 3-days incraesed memory retrieval. However, repeated administration of different doses of morphine (2.5, 5 and 10 mg /kg) for 3-days reversed amnesia induced by WIN55, 212-2.
Conclusion: The results suggest that cannabinoidergic and opioidegic system have a close interaction on memory retrieval and WIN55, 212-2 influence on memory formation and subchronic morphine pre-treatment may restore memory through a possible opioidergic receptor sensitization.

 
Keyword(s): CANNABINOIDS, MORPHINE, DORSAL HIPPOCAMPUS, SENSITIZATION, PASSIVE AVOIDANCE LEARNING
 
References: 
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