Wang et al. have provided new and novel evidence about the importance of using a-fetoprotein (ALP) and glypican-3 (GPC-3) mRNA detection in peripheral blood of the patients with hepatocellular carcinoma (HCC) recurrence after ortothopic liver transplantation (OLT) (1). HCC keeps on as major universal health apprehension ensuing in more than 1 million caner associated deaths annually (2, 3)….