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Paper Information

Journal:   IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)   WINTER 2011 , Volume 10 , Number 1; Page(s) 63 To 67.
 
Paper: 

HEPATOPROTECTIVE EFFECT OF FICUS CARICA LEAF EXTRACT ON MICE INTOXICATED WITH CARBON TETRACHLORIDE

 
 
Author(s):  AGHEL N.*, KALANTARI H.A., REZAZADEH SH.
 
* MEDICINAL PLANT RESEARCH CENTER, JOUNDISHAPOUR MEDICAL SCIENCES UNIVERSITY, AHWAZ, IRAN
 
Abstract: 

Protective action of Ficus carica leaf ethanolic extract (obtained by maceration) was evaluated in an animal model of hepatotoxicity induced by carbon tetrachloride (CCl4).

Male albino mice were divided into six groups. Group I was normal control group; group II received olive oil (CCl4 solvent), groups III-VI received CCl4. After inducing hepatic damage, group III served as control for CCl4; and groups IV- VI received different doses of Ficus carica ethanol extract (200, 400 and 800 mg/kg) prior to intoxication with CCl4. Liver marker enzymes were assayed in serum. Sections of livers were observed under microscope for the histopathological changes. Levels of marker enzymes such as alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were increased significantly in CCl4 treated mice (group III). In groups IV, V and VI, pre-treated with the plant extract and intoxicated with CCl4, decreased activities of these two enzymes were observed. Also, pre-treatment with the extract in these groups resulted in less pronounced destruction of the liver architecture with no fibrosis and moderate inflammation was observed compared with group III. The present observations suggested that the treatment with Ficus carica leaf extract in dose of 200 mg/kg enhanced protection against CCl4 induced hepatic damage.

 
Keyword(s): FICUS CARICA, LIVER, CARBON TETRACHLORIDE, HEPATOPROTECTIVE, MICE
 
 
References: 
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+ Click to Cite.
APA: Copy

AGHEL, N., & KALANTARI, H., & REZAZADEH, S. (2011). HEPATOPROTECTIVE EFFECT OF FICUS CARICA LEAF EXTRACT ON MICE INTOXICATED WITH CARBON TETRACHLORIDE. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 10(1), 63-67. https://www.sid.ir/en/journal/ViewPaper.aspx?id=191711



Vancouver: Copy

AGHEL N., KALANTARI H.A., REZAZADEH SH.. HEPATOPROTECTIVE EFFECT OF FICUS CARICA LEAF EXTRACT ON MICE INTOXICATED WITH CARBON TETRACHLORIDE. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR). 2011 [cited 2021June22];10(1):63-67. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=191711



IEEE: Copy

AGHEL, N., KALANTARI, H., REZAZADEH, S., 2011. HEPATOPROTECTIVE EFFECT OF FICUS CARICA LEAF EXTRACT ON MICE INTOXICATED WITH CARBON TETRACHLORIDE. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), [online] 10(1), pp.63-67. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=191711.



 
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