Click for new scientific resources and news about Corona[COVID-19]

Paper Information

Journal:   IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES   JANUARY-FEBRUARY 2011 , Volume 14 , Number 1 (48); Page(s) 49 To 56.
 
Paper: 

THE EFFECT OF CHRONIC ADMINISTRATION OF AEGLE MARMELOS SEED EXTRACT ON LEARNING AND MEMORY IN DIABETIC RATS

 
 
Author(s):  FARSHCHI AMIR*, GHIASI GOLBARG, FARSHCHI SAMIREH, GHOBADI AMIN TALEB
 
* SCHOOL OF PHARMACY, KERMANSHAH UNIVERSITY OF MEDICAL SCIENCES, KERMANSHAH, IRAN
 
Abstract: 
Objective(s)
Diabetes mellitus is associated with disturbances of learning and memory and cognitive functioning. Aegle marmelos Corr. from Rutaceae family is widely used in Iranian folk medicine for the treatment of diabetes mellitus. Considering the beneficial antidiabetic and antioxidant potential of A. marmelos, this study was conducted to evaluate the effect of oral administration of A. marmelos on learning and spatial memory in diabetic rats using Morris water maze test.
Materials and Methods
Considering the beneficial antidiabetic potential of A. marmelos, this study was conducted to evaluate the effect of chronic oral administration of A. marmelos as cognitive enhancer, on learning and spatial memory in diabetic rats using Morris water maze test. Male Wistar rats were randomly divided into normal-control, diabetic-control, and A. marmelos-treated diabetic groups (100, 250 and 500 mg/kg, p.o.). Animals were treated for 4 weeks by A. marmelos or normal saline. Diabetes was induced by a single dose i.p. injection of streptozotocin (45 mg/kg). In each group of animals, spatial learning and memory parameters were analyzed.
Results
Clear impairment of spatial learning and memory was observed in diabetic group versus normal-control group. A. marmelos showed dose dependent improvement in spatial learning and memory parameters that swimming time (Escape Latency) in normal-control and A. marmelos-treated diabetic animals rats was significantly (P< 0.01) lower than diabetic-control, while swimming speed was significantly (P< 0.05) higher.
Conclusion
The study demonstrated that A. marmelos has significant protective affect against diabetes-induced spatial learning and memory deficits. This effect could be attributed to hypoglycemic, hypolipidemic and antioxidant activity of A. marmelos.
 
Keyword(s): AEGLE MARMELOS, DIABETES, MORRIS WATER MAZE, SPATIAL LEARNING AND MEMORY
 
 
References: 
 
Citations: 
  • Not Registered.
 
+ Click to Cite.
APA: Copy

FARSHCHI, A., & GHIASI, G., & FARSHCHI, S., & GHOBADI, A. (2011). THE EFFECT OF CHRONIC ADMINISTRATION OF AEGLE MARMELOS SEED EXTRACT ON LEARNING AND MEMORY IN DIABETIC RATS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 14(1 (48)), 49-56. https://www.sid.ir/en/journal/ViewPaper.aspx?id=191709



Vancouver: Copy

FARSHCHI AMIR, GHIASI GOLBARG, FARSHCHI SAMIREH, GHOBADI AMIN TALEB. THE EFFECT OF CHRONIC ADMINISTRATION OF AEGLE MARMELOS SEED EXTRACT ON LEARNING AND MEMORY IN DIABETIC RATS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES. 2011 [cited 2021June22];14(1 (48)):49-56. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=191709



IEEE: Copy

FARSHCHI, A., GHIASI, G., FARSHCHI, S., GHOBADI, A., 2011. THE EFFECT OF CHRONIC ADMINISTRATION OF AEGLE MARMELOS SEED EXTRACT ON LEARNING AND MEMORY IN DIABETIC RATS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, [online] 14(1 (48)), pp.49-56. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=191709.



 
  pdf-File
Yearly Visit 60
 
 
Latest on Blog
Enter SID Blog