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Paper Information

Journal:   BIOLOGICAL SCIENCES (DANISH-I ZISTI-I IRAN)   SPRING 2009 , Volume 4 , Number 1; Page(s) 15 To 20.
 
Paper: 

ANTIDEPRESSANT EFFECT OF RED GINSENG HYDRO-ALCOHOLIC EXTRACT BY FORCED SWIMMING AND TAIL SUSPENSION TESTS IN FEMALE MICE

 
 
Author(s):  KHAKPOUR SH., KHOSRAVI M.*, MASOOMPOUR ASKARI S.
 
* MEDICAL SCIENCE RESEARCH CENTER, ISLAMIC AZAD UNIVERSITY, TEHRAN MEDICAL BRANCH, TEHRAN, IRAN
 
Abstract: 

Depression is one of the most frequently occurring disorders, affecting about 10-15% of the population each year. The pharmacological approach to the treatment of depression includes a long-term employment of antidepressants, either in the form of monotherapy or as a combination of several antidepressants with various mechanisms of action Red ginseng constituents to be an effective alternative to other therapeutic agents in the treatment of mild to moderate depression. Several constituents of the extract, such as ginsenosid seem to be important for this effect. The study the investigate antidepressant effect of Red ginseng root on female mice using the forced swimming (Fst) and the tail-suspension tests (Tst). Seven groups of mice were used in this experiment. The first group is control and second groups received saline and third group received fluoxetine (10 mg/kg/day). Four other groups were treated with one of the doses of root extract (25, 50, 100, 200 mg/kg/day) by intraperitoneal injection (ip) for five days. Groups treated with fluoxetine and extract of Red ginseng root had significantly shorter immobility times compared to the control group in Fst and Tst (p<0.05), i.e. the activity of the animals was higher. The results demonstrated that Red ginseng had specifically antidepressant-like effect in vivo. The activity of Red ginseng in antidepression may be mediated in part through up take inhibition of serotonin in mice brain. When animals forced to swim in a cylinder pool or tail suspension in this method, they, after awhile, became immobile which was an indicator of their depressive states.

 
Keyword(s): DEPRESSION, RED GINSENG ROOT, FORCED SWIMMING TEST, TAIL-SUSPENSION TEST, FEMALE MICE
 
References: 
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