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Paper Information

Journal:   BIOLOGICAL SCIENCES (DANISH-I ZISTI-I IRAN)   SPRING 2009 , Volume 4 , Number 1; Page(s) 9 To 14.
 
Paper: 

HYPOGLYCAEMIC EFFECT OF ETHANOLIC EXTRACT LEAVES OF ALLIUM AMPELOPRASUM L. SUBSP. IRANICUM IN HEALTHY AND DIABETIC NMARI MICE

 
 
Author(s):  KHALAJI S., EIDI M.*, EIDI A., SHAHMOHAMMADI P., ARAB M.
 
* DEPARTMENT OF BIOLOGY, VARAMIN BRANCH, ISLAMIC AZAD UNIVERSITY, TEHRAN, IRAN
 
Abstract: 

In the present study, the effect of the ethanolic extract of leaves of Allium ampeloprasum L. subsp. iranicum on body, kidney and liver weights, serum glucose and insulin levels were investigated in both normal and streptozotocin-induced diabetic NMARI mice. The animals were made diabetic using by streptozotocin (175 mg/kg, i.p.). The ethanolic extract at doses 100, 150, 200, 250, 300 and 400 mg / kg, i.p. were administered for 16 days intraperitoneally. Blood samples were obtained from heart after 16 days. The groups of normal and diabetic mice were administered saline as control groups. Serum glucose and insulin levels were measured by enzymatic and radioimmunoassay methods, respectively. The results showed that the ethanolic extract of Allium ampeloprasum didn't change body, kidney and liver weights in treated diabetic and normal animals significantly. On the other hand, ethanolic extract of Allium ampeloprasum reduced the serum glucose, while increased serum insulin levels significantly. The significant compound of leek is unknown yet. The present data indicates that extract of Allium ampeloprasum has hypoglycaemic effect on diabetic animals. So, this plant should be considered in future therapeutic researches.

 
Keyword(s): ALLIUM AMPELOPRASUM, LEEK, LEAVES, HYPOGLYCAEMIA, DIABETES, MICE
 
References: 
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