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Journal:   IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES   MARCH-APRIL 2011 , Volume 14 , Number 2 (49); Page(s) 185 To 189.
 
Paper: 

Assessment Of Vegf, Cd-31 And Ki-67 Immunohistochemical Markers In Oral Pyogenic Granuloma: A Comparison With Hemangioma And Inflammatory Gingivitis

 
 
Author(s):  Saghafi Shadi, Amoueian Sakineh*, Montazer Mehdi, Bostan Roshanak
 
* IMAM-REZA HOSPITAL, MASHHAD UNIVERSITY OF MEDICAL SCIENCES, MASHHAD, IRAN
 
Abstract: 
Objective(s) The aim of this study was to evaluate the expressions of two angiogenic immune-markers (CD-31 and VEGF), and one proliferative immune-marker (Ki-67) in oral pyogenic granulomas (PG), hemangiomas (Hem) and inflammatory gingivitis (IG). Materials and Methods Sixty cases of PG, Hem and IG (twenty cases each) were examined. Immunohistochemical (IHC) staining was performed based on routine techniques. The microvessel density (MVD) index was also evaluated. Results The male to female ratio was 1:2. The mean age was 33.3 years old (±20.52). The reactivity percentages for all three markers (CD-31, VEGF and Ki-67) were significantly higher in PG compared to Hem (56.8%, 13.8% and 23.0% vs. 28.3%, 7.0% and 5.4%, respectively). The mean MVD in PG was also significantly higher than in Hem (26.1±0.11 vs.13.6±0.08). There was no statistically significant difference between PG and IG. Conclusion The current study supports the common nature of pyogenic granulomas and inflammatory gingivitis.
 
Keyword(s): CD31, GINGIVITIS, HEMANGIOMA, KI-67 ANTIGEN, PYOGENIC GRANULOMA, VEGF
 
 
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APA: Copy

SAGHAFI, S., & AMOUEIAN, S., & MONTAZER, M., & BOSTAN, R. (2011). ASSESSMENT OF VEGF, CD-31 AND KI-67 IMMUNOHISTOCHEMICAL MARKERS IN ORAL PYOGENIC GRANULOMA: A COMPARISON WITH HEMANGIOMA AND INFLAMMATORY GINGIVITIS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 14(2 (49)), 185-189. https://www.sid.ir/en/journal/ViewPaper.aspx?id=191317



Vancouver: Copy

SAGHAFI SHADI, AMOUEIAN SAKINEH, MONTAZER MEHDI, BOSTAN ROSHANAK. ASSESSMENT OF VEGF, CD-31 AND KI-67 IMMUNOHISTOCHEMICAL MARKERS IN ORAL PYOGENIC GRANULOMA: A COMPARISON WITH HEMANGIOMA AND INFLAMMATORY GINGIVITIS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES. 2011 [cited 2022August18];14(2 (49)):185-189. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=191317



IEEE: Copy

SAGHAFI, S., AMOUEIAN, S., MONTAZER, M., BOSTAN, R., 2011. ASSESSMENT OF VEGF, CD-31 AND KI-67 IMMUNOHISTOCHEMICAL MARKERS IN ORAL PYOGENIC GRANULOMA: A COMPARISON WITH HEMANGIOMA AND INFLAMMATORY GINGIVITIS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, [online] 14(2 (49)), pp.185-189. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=191317.



 
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