Paper Information

Journal:   IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES   MARCH-APRIL 2011 , Volume 14 , Number 2 (49); Page(s) 185 To 189.
 
Paper: 

ASSESSMENT OF VEGF, CD-31 AND KI-67 IMMUNOHISTOCHEMICAL MARKERS IN ORAL PYOGENIC GRANULOMA: A COMPARISON WITH HEMANGIOMA AND INFLAMMATORY GINGIVITIS

 
 
Author(s):  SAGHAFI SHADI, AMOUEIAN SAKINEH*, MONTAZER MEHDI, BOSTAN ROSHANAK
 
* IMAM-REZA HOSPITAL, MASHHAD UNIVERSITY OF MEDICAL SCIENCES, MASHHAD, IRAN
 
Abstract: 
Objective(s)
The aim of this study was to evaluate the expressions of two angiogenic immune-markers (CD-31 and VEGF), and one proliferative immune-marker (Ki-67) in oral pyogenic granulomas (PG), hemangiomas (Hem) and inflammatory gingivitis (IG).
Materials and Methods
Sixty cases of PG, Hem and IG (twenty cases each) were examined. Immunohistochemical (IHC) staining was performed based on routine techniques. The microvessel density (MVD) index was also evaluated.
Results
The male to female ratio was 1:2. The mean age was 33.3 years old (±20.52). The reactivity percentages for all three markers (CD-31, VEGF and Ki-67) were significantly higher in PG compared to Hem (56.8%, 13.8% and 23.0% vs. 28.3%, 7.0% and 5.4%, respectively). The mean MVD in PG was also significantly higher than in Hem (26.1±0.11 vs.13.6±0.08). There was no statistically significant difference between PG and IG.
Conclusion
The current study supports the common nature of pyogenic granulomas and inflammatory gingivitis.
 
Keyword(s): CD31, GINGIVITIS, HEMANGIOMA, KI-67 ANTIGEN, PYOGENIC GRANULOMA, VEGF
 
References: 
  • ندارد
 
  pdf-File tarjomyar Yearly Visit 63
 
Latest on Blog
Enter SID Blog