Paper Information

Journal:   IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES   MARCH-APRIL 2011 , Volume 14 , Number 2 (49); Page(s) 107 To 115.
 
Paper:  EFFECT OF DEXAMETHASONE ON STRIATAL NEUROTRANSMISSIONS IN THE RATS SUBJECTED TO PARKINSON’S DISEASE ANIMAL MODEL
 
Author(s):  AMANLOU MASSOUD, SIADAT SEYED DAVAR, NOROUZIAN DARIUSH, AGHASADEGHI MOHAMMAD REZA, FATHI MOGHADDAM HADI, PIRYAEI MOHHAMAD, SHAFIEE ARDESTANI MEHDI*
 
* DEPARTMENT OF MEDICINAL CHEMISTRY, FACULTY OF PHARMACY, TEHRAN UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, IRAN
 
Abstract: 
Objectiv(s)
The aim of this study was to evaluate the effects of dexamethasone on striatal dopaminergic, glutamatergic and gamma amino butyric acid (GABA) ergic neurotransmission in normal and parkinsonian rats.
Materials and Methods
Dexamethasone (0.15, 0.30, 0.60 and 0.8 mg/kg) was administered to normal or parkinsonian rats (i.p.) followed by the analysis of the striatal neurotransmitters concentrations. Additionally, the effect of dexamethasone on the damaged Substantia nigra pars compata (SNc) neurons has been investigated.
Results
Dexamethasone resulted in decreased level of striatum glutamatergic-GABAergic and enhanced dopaminergic neurotransmission in normal and parkinsonian rats. In addition, acute treatment with dexamethasone did not improve the lesion at all.
Conclusion
These findings suggest the new therapeutic mechanism of action for dexamethasone in Parkinson’s disease animal model.
 
Keyword(s): DEXAMETHASONE, DOPAMINE, GABA, GLUTAMATE, PARKINSON’S DISEASE
 
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