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Paper Information

Journal:   IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES   MARCH-APRIL 2011 , Volume 14 , Number 2 (49); Page(s) 99 To 106.
 
Paper: 

PREVENTIVE EFFECT OF VITAMIN B6 ON DEVELOPMENTAL TOXICITY OF CARBAMAZEPINE IN MICE

 
 
Author(s):  AFSHAR MOHAMMAD, MOALLEM SEYED ADEL*, BAHARARA JAVAD, TAKJO TOKTAM, JAFARGOLALIPOUR MOHAMMAD
 
* PHARMACEUTICAL SCIENCES RESEARCH CENTER, MEDICAL TOXICOLOGY RESEARCH CENTER, DEPARTMENT OF PHARMACODYNAMICS AND TOXICOLOGY, MASHHAD UNIVERSITY OF MEDICAL SCIENCES, MASHHAD, IRAN
 
Abstract: 
Objective(s)
Carbamazepine (CBZ) is an antiepileptic drug that is used widely for the treatment of epileptic seizures.
Neural tube defects (NTDs), growth retardation, and nail hypoplasia are the most common features of teratogenic effects of this drug. The purpose of this study was to examine the effect of vitamin B6 on the developmental toxicity of CBZ on mice.
Materials and Methods
Sixty BALB/c pregnant mice were divided into four experimental and two control groups. Two experimental groups received daily intraperitoneal injection (IP) of 30 mg/kg (I) or 60 mg/kg (II) of CBZ on gestational days (GD) 6 to 15. Two other experimental groups received daily IP injection of 30 mg/kg (III) or 60 mg/kg (IV) of CBZ with 10 mg/kg/day vitamin B6 by gavage 10 days prior to gestation and on GD 6 to 15. Two control groups received normal saline or Tween 20. Dams underwent Cesarean section on GD 18 and embryos were harvested. External/macroscopic observation of fetuses was done by stereomicroscope and external examination for malformations was recorded. Data analyzed by ANOVA and X2 test using SPSS software.
Results
The mean weight and crown-rump of the fetuses in both CBZ-treated experimental groups were significantly reduced compared with those of the control groups. Various malformations were detected such as brachygnathia, eye malformations, NTDs, vertebral deformity, brachydactyly and growth retardation.
Vitamin B6 treatment significantly reduced various CBZ-induced malformations.
Conclusion
This study showed that vitamin B6 has a preventive effect on the developmental toxicity of CBZ in mice that can be pursued further for clinical research.
 
Keyword(s): CARBAMAZEPINE, CONGENITAL ABNORMALITIES, PYRIDOXINE, TERATOLOGY, MICE
 
 
References: 
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Citations: 
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APA: Copy

AFSHAR, M., & MOALLEM, S., & BAHARARA, J., & TAKJO, T., & JAFARGOLALIPOUR, M. (2011). PREVENTIVE EFFECT OF VITAMIN B6 ON DEVELOPMENTAL TOXICITY OF CARBAMAZEPINE IN MICE. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 14(2 (49)), 99-106. https://www.sid.ir/en/journal/ViewPaper.aspx?id=191281



Vancouver: Copy

AFSHAR MOHAMMAD, MOALLEM SEYED ADEL, BAHARARA JAVAD, TAKJO TOKTAM, JAFARGOLALIPOUR MOHAMMAD. PREVENTIVE EFFECT OF VITAMIN B6 ON DEVELOPMENTAL TOXICITY OF CARBAMAZEPINE IN MICE. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES. 2011 [cited 2021June22];14(2 (49)):99-106. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=191281



IEEE: Copy

AFSHAR, M., MOALLEM, S., BAHARARA, J., TAKJO, T., JAFARGOLALIPOUR, M., 2011. PREVENTIVE EFFECT OF VITAMIN B6 ON DEVELOPMENTAL TOXICITY OF CARBAMAZEPINE IN MICE. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, [online] 14(2 (49)), pp.99-106. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=191281.



 
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