Paper Information

Journal:   JOURNAL OF KERMAN UNIVERSITY OF MEDICAL SCIENCES   SPRING 2011 , Volume 18 , Number 2; Page(s) 144 To 153.
 
Paper: 

THE EFFECT OF FLAVONOID NARINGENIN ON CONTRACTILE RESPONSE OF THORACIC AORTA ISOLATED FROM DIABETIC RATS

 
 
Author(s):  FALLAHI FARAMARZ, NASRI K., ROGHANI MEHRDAD*
 
* DEPARTMENT OF PHYSIOLOGY, SCHOOL OF MEDICINE AND MEDICINAL PLANT RESEARCH CENTER, SHAHED UNIVERSITY, TEHRAN, IRAN
 
Abstract: 

Background & Aims: Considering increasing incidence of cardiovascular disorders in diabetes mellitus and some evidence on antioxidant and antidiabetic potentials of naringenin, this study was conducted to evaluate the beneficial effects of 6-week administration of naringenin on contractile reactivity of isolated thoracic aorta in diabetic rats.
Methods: Male Wistar rats were divided into control, naringenin-treated control, diabetic and glibenclamide-treated, and naringenin-treated diabetic groups. For induction of diabetes, streptozotcin (STZ) was administered (60 mg/Kg). Naringenin (10 mg/kg) was administered i.p. one week after diabetes induction in every other day intervals for 6 weeks. Serum glucose level was measured before naringenin administration and at 6th week. Finally, contractile reactivity of thoracic aortic rings to KCl and phenylephrine (PE) was cumulatively determined.
Results: Serum glucose level at week 6 showed a significant decrease in naringenin-treated diabetic group compared to diabetics (P<0.01). In addition, naringenin-treated diabetic group showed a significantly lower contraction to PE (P<0.05) as compared to diabetic group and such significant reduction was also observed for KCl (P<0.05). Meanwhile, there was also a significant difference between control and naringenin-treated control groups regarding their contractile reactivity to PE (P<0.05).
Conclusion: Subchronic administration of naringenin for 6 weeks could exert an anti-hyperglycemic effect and lowers contractile responsiveness of thoracic aorta rings to KCl and phenylephrine.

 
Keyword(s): NARINGENIN, DIABETES MELLITUS, AORTA, CONTRACTILITY
 
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