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Paper Information

Journal:   RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES)   JUNE 2010 , Volume 17 , Number 72; Page(s) 42 To 48.
 
Paper: 

ASSOCIATION OF M55V POLYMORPHISM OF SUMO4 WITH TYPE 2 DIABETES

 
 
Author(s):  FALAH SOUDABEH*, JAFARZADEH M., HEDAYATI MAHDI, HAJHOSSEINI R.
 
* IRAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES, TEHRAN, IRAN
 
Abstract: 

Background & Aim: Sumo4 has recently been found to be mainly expressed in kidney. Single nucleotide polymorphism, which is detected in sumo4, replaces a highly conserved methionine with a valine (M55V) residue. This variant of sumo4 may induce higher nuclear factor–KB (NFKB) activity because NFKB is known to mediate the development of diabetic nephropathy.
Patients and Method: This study involved 50 patients with type 2 diabetes and 50 healthy subjects. The M55V polymorphism of sumo4 was genotyped by PCR and restriction enzyme digestion. The serum glucose concentration was measured by enzymatic method. Students' t-test and Chi-square test were used to analyze the data
Results: The frequency of sumo4 AA, GA and GG was 20%, 44% and 36% in the case group and 26%, 50% and 24% in the control group respectively.
Conclusion: The results suggest that the sumo4 M55V variant is not associated with type 2 diabetes mellitus susceptibility, suggesting that it may not be involved in the pathogenesis of type 2 diabetes.

 
Keyword(s): DIABETES, POLYMORPHISM, MUTATION, RESTRICTION ENZYME, SUMO4 GENE
 
 
References: 
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Citations: 
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APA: Copy

FALAH, S., & JAFARZADEH, M., & HEDAYATI, M., & HAJHOSSEINI, R. (2010). ASSOCIATION OF M55V POLYMORPHISM OF SUMO4 WITH TYPE 2 DIABETES. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), 17(72), 42-48. https://www.sid.ir/en/journal/ViewPaper.aspx?id=190960



Vancouver: Copy

FALAH SOUDABEH, JAFARZADEH M., HEDAYATI MAHDI, HAJHOSSEINI R.. ASSOCIATION OF M55V POLYMORPHISM OF SUMO4 WITH TYPE 2 DIABETES. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES). 2010 [cited 2021June22];17(72):42-48. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=190960



IEEE: Copy

FALAH, S., JAFARZADEH, M., HEDAYATI, M., HAJHOSSEINI, R., 2010. ASSOCIATION OF M55V POLYMORPHISM OF SUMO4 WITH TYPE 2 DIABETES. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), [online] 17(72), pp.42-48. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=190960.



 
 
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