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Paper Information

Journal:   INTERNATIONAL JOURNAL OF INDUSTRIAL CHEMISTRY (IJIC)   MARCH 2011 , Volume 2 , Number 1; Page(s) 45 To 51.
 
Paper: 

SYNTHESIS OF SOME NEW THIAZOLIDINONES DERIVED FROM 1-P-TOLYLETHANONE AND THEIR ANTIBACTERIAL AND ANTIFUNGAL ACTIVITIES

 
 
Author(s):  PATEL J.B., DESAI V.A.*
 
* DEPARTMENT OF CHEMISTRY, B.K.M. SCIENCE COLLEGE, VALSAD, 396001, GUJARAT, INDIA
 
Abstract: 
Some new 3- (substitutedphenyl) -2-methyl-2-p-tolylthiazolidin-4-ones (3a-t) were prepared by refluxing the 1-p-tolylethanone (1) with different aromatic amines (2a-t) in presence of thioglycolic acid in benzene (one pot synthesis). The title compounds have been characterized on the basis of elemental analysis, IR, 1 H-NMR and13 C-NMR spectral data. All the synthesized compounds have been screened against four different bacterial strains S. aureus, S. paratyphi-A, E. coli and B. subtilis and fungal strain F. molaniforme and A. niger. Some of them showed good antibacterial and antifungal activity compared to reference drugs used in the study.
 
Keyword(s): ANTIBACTERIAL, ANTIFUNGAL, ONE POT SYNTHESIS, 1-P-TOLYLETHANONE
 
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