Dear Editor: Several lines of evidence imply that hepatitis D virus (HDV) infection has a worldwide distribution. It is quite common in some areas such as Russia, Romania, Southern Italy, Medi terranean countries, Africa, South American (Venezuela, Columbia, Brazil, and Ecuador) and China (1). We conducted this study to determine the seroprevalence of HDV in Shahrekord, a small city in Charmahal-o-Bakhtiyari province, West of Iran and compared it with the results of studies carried out in the larger cities in Iran. We studied 11,472 (9602 men and 1870 women) volunteer blood donors.