Click for new scientific resources and news about Corona[COVID-19]

Paper Information

Journal:   HEPATITIS MONTHLY   FEBRUARY 2011 , Volume 11 , Number 2 (31); Page(s) 86 To 91.
 
Paper: 

GENOTYPES, MUTATIONS, AND VIRAL LOAD OF HEPATITIS B VIRUS AND THE RISK OF HEPATOCELLULAR CARCINOMA

 
 
Author(s):  ZHANG Q., CAO G.*
 
* DEPARTMENT OF EPIDEMIOLOGY, SECOND MILITARY MEDICAL UNIVERSITY, 800 XIANGYIN RD, SHANGHAI 200433, CHINA
 
Abstract: 

Chronic infection with hepatitis B virus (HBV) is the major risk factor for hepatocellular car­cinoma (HCC) worldwide. Ten HBV genotypes (A-J) have been discovered so far. Genotypes B and C are endemic in East and Southeast Asia. Genotype C HBV is associated with increased risks of cirrhosis and HCC. Genotype B (B2) is associated with the development of HCC in non-cirrhotic patients younger than 50 years and with relapse of HCC after surgical treatment. It is also associated with earlier hepatitis B e antigen seroconversion than genotype C. High HBV load is independently associated with the occurrence and post-treatment recurrence of HCC. Different genotypes have distinct patterns of mutations. Viral mutations in the core promoter region and in the preS region are frequently found to be significantly associated with an in­creased risk of HCC. These mutations often occur before the onset of HCC and accumulate during the progression of chronic HBV infection. Multiple such mutations are more frequent in patients with HCC and are specific for HCC. HBV subgenotypes, viral mutations, and viral load can be used for the prediction of HCC. Early identification of HBV-infected individuals who will eventually develop HCC will help to develop active prophylactic protocols to reduce or delay the occurrence of HCC.

 
Keyword(s): HEPATOCELLULAR CARCINOMA HEPATITIS B VIRUS, GENOTYPE, MUTATION
 
 
References: 
  • Not Registered.
  •  
  •  
 
Citations: 
  • Not Registered.
 
+ Click to Cite.
APA: Copy

ZHANG, Q., & Cao, G. (2011). GENOTYPES, MUTATIONS, AND VIRAL LOAD OF HEPATITIS B VIRUS AND THE RISK OF HEPATOCELLULAR CARCINOMA. HEPATITIS MONTHLY, 11(2 (31)), 86-91. https://www.sid.ir/en/journal/ViewPaper.aspx?id=190419



Vancouver: Copy

ZHANG Q., Cao G.. GENOTYPES, MUTATIONS, AND VIRAL LOAD OF HEPATITIS B VIRUS AND THE RISK OF HEPATOCELLULAR CARCINOMA. HEPATITIS MONTHLY. 2011 [cited 2021August04];11(2 (31)):86-91. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=190419



IEEE: Copy

ZHANG, Q., Cao, G., 2011. GENOTYPES, MUTATIONS, AND VIRAL LOAD OF HEPATITIS B VIRUS AND THE RISK OF HEPATOCELLULAR CARCINOMA. HEPATITIS MONTHLY, [online] 11(2 (31)), pp.86-91. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=190419.



 
  pdf-File
Yearly Visit 194
 
 
Latest on Blog
Enter SID Blog