Paper Information

Journal:   JOURNAL OF LARGE ANIMAL CLINICAL SCIENCE RESEARCH (JOURNAL OF VETERINARY MEDICINE)   2008 , Volume 2 , Number 5; Page(s) 21 To 27.
 
Paper: 

EVALUATION OF SERUMS LEVELS OF GLUCOSE, LIPIDS AND LIPOPROTEINS AFTER INDUCED 3, 4 METHYLENEDIOXYMETH AMPHETAMINE (MDMA, ECSTASY) IN DOG

 
 
Author(s):  AMOU OUGHLI TABRIZI B.*, KHAYAT NOURI H., ASADZADEH K., ZARGARZADEH A.
 
* DEPARTMENT OF CLINICAL SCIENCES, VETERINARY FACULTY, ISLAMIC AZAD UNIVERSITY, TABRIZ BRANCH, TABRIZ, IRAN
 
Abstract: 

In order to evaluate the effect of Ecstasy on glucose, lipids and lipoproteins metabolism, Five 3.5 - 4 years old male mixed breed dogs were selected. Blood samples were collected and recorded as time zero or control sampels before drug administration. Then, each dog was given Ecstasy tables orally at a single dose (150 mg/kg). Blood samples were collected from the cephalic vein at time intervals of 30 minutes, 1, 2, 4, 8, 24, 48 hours and 7 and 20 days following administration. Serum levels of Glucose, Triglyceride, Cholesterol, HDL, LDL and VLDL were measured by colorimetric method using spectrophotometer and commercial diagnostic kits (ziest chem). The results of this study showed significant increase in serumic levels of Glucose, Cholesterol and LDL, and Triglyceride VLDL up to 24 hours following drug adminstration that could be due to the effect of drug on liver and body metabolism(p<0.05). But Serum levels of HDL was not significant (p>0.05) after this time. Therefore, using MDMA even for the short time and single dose could be affected on normal function of liver and could change metabolism of lipids and lipoproteins.

 
Keyword(s): ECSTASY, GLUCOSE, TRIGLYCERIDE, CHOLESTEROL, LIPOPROTEINS, DOG
 
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