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Paper Information

Journal:   JOURNAL OF LARGE ANIMAL CLINICAL SCIENCE RESEARCH (JOURNAL OF VETERINARY MEDICINE)   FALL 2008 , Volume 2 , Number 4; Page(s) 23 To 30.
 
Paper: 

STUDY OF ALTERATION OF KETAMINE HYDROCHLORIDE PH EFFECTS ON EPIDURAL ANALGESIA IN CHALL SHEEP

 
 
Author(s):  NAJAFPOUR A.R.*, POURMASOUM GHARAHBAGH A.
 
* DEPARTMENT OF CLINICAL STUDIES, FACULTY OF VETERINARY MEDICINE, ISLAMIC AZAD UNIVERSITY URMIA BRANCH, URMIA, IRAN
 
Abstract: 

Using some anesthesia drugs such as ketamine in addition to analgesia drugs is common in different animal species currently.
As pH rises, the membrane permeability of the analgesic drug and its diffusion in the neural lipid sheath increases fast and diffusion of the drug increases the analgesia effect and duration of action on the internal parts and axons. In this study, by using 1 molar sodium carbonate, the commercial ketamine pH, which is 4.60
± 0.01, has been altered to 5.60 ± 0.01 and 6.60 ± 0.01. Nine healthy Chall sheep with an average weight of 38/89±13.29 kg were selected randomly; one ml per 20 Kg body weight of each of the prepared solutions was injected in the epidural space between the last lumbar and the first sacral (L6-S1) vertebrae.
The time of induction and completion of ventral and the caudal regions analgesia and its recovery time were recorded by taking advantage of the needle method (Pin Prick). Statistical analysis of the results showed that the increase in the commercial ketamine pH to 5.6
±0.01 and 6.6±0.01 caused significant differences in the induction time of analgesia in rump region, completion of analgesia in perineal and caudal region of the hind limbs. So alkalinization of ketamine leads to local anesthesia as well as general sedation in animal. The results showed no change of drug properties in operations on the caudal region in sheep alkalinized.

 
Keyword(s): KETAMINE HCL, EPIDURAL ANALGESIA, PH, CHALL SHEEP
 
 
References: 
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Citations: 
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+ Click to Cite.
APA: Copy

NAJAFPOUR, A., & POURMASOUM GHARAHBAGH, A. (2008). STUDY OF ALTERATION OF KETAMINE HYDROCHLORIDE PH EFFECTS ON EPIDURAL ANALGESIA IN CHALL SHEEP. JOURNAL OF LARGE ANIMAL CLINICAL SCIENCE RESEARCH (JOURNAL OF VETERINARY MEDICINE), 2(4), 23-30. https://www.sid.ir/en/journal/ViewPaper.aspx?id=190006



Vancouver: Copy

NAJAFPOUR A.R., POURMASOUM GHARAHBAGH A.. STUDY OF ALTERATION OF KETAMINE HYDROCHLORIDE PH EFFECTS ON EPIDURAL ANALGESIA IN CHALL SHEEP. JOURNAL OF LARGE ANIMAL CLINICAL SCIENCE RESEARCH (JOURNAL OF VETERINARY MEDICINE). 2008 [cited 2021August04];2(4):23-30. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=190006



IEEE: Copy

NAJAFPOUR, A., POURMASOUM GHARAHBAGH, A., 2008. STUDY OF ALTERATION OF KETAMINE HYDROCHLORIDE PH EFFECTS ON EPIDURAL ANALGESIA IN CHALL SHEEP. JOURNAL OF LARGE ANIMAL CLINICAL SCIENCE RESEARCH (JOURNAL OF VETERINARY MEDICINE), [online] 2(4), pp.23-30. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=190006.



 
 
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