Paper Information

Journal:   JOURNAL OF MICROBIAL BIOTECHNOLOGY   FALL 2009 , Volume 1 , Number 2 (2); Page(s) 31 To 36.
 
Paper: 

EVALUATION OF THE SERUM IL-17 AND IL-23 LEVELS IN HELICOBACTER PYLORI-INFECTED PEPTIC ULCER PATIENTS

 
 
Author(s):  JAFARZADEH A.A.*, MIRZAEI V., NEMATI M., REZAYATI M.T, AHMAD BEYGI H.
 
* DEPARTMENT OF MICROBIOLOGY AND IMMUNOLOGY, MEDICAL SCHOOL, RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES
 
Abstract: 

Background and Objective: H.pylori is a major etiologic agent for several gastroduoedenal diseases including gastric ulcer and peptic ulcer. It has been reported that the Th17 cells strongly associated with inflammatory disease and IL-23 presented as a main inducer of Th17 cells development. The aim of this study was to investigate the serum levels of IL-17 and IL-23 in H. pylori-infected peptic ulcer (PU) patients and H. pylori-infected asymptomatic (AS) carriers.
Materials and Methods: Totally, 45 H. pylori-infected PU patients, 30 H. pylori-infected AS carriers and 15 healthy uninfected subjects (as a control group) were enrolled to study. A blood sample was obtained from all participants and the serum levels of IL-17 and IL-23 was measured by ELISA method.
Results: The mean serum levels of IL-17 in total PU patients (9.28 pg/ml
± 5.48) was significantly higher than those observed in total AS subjects (5.19 pg/ml ± 3.75, p<0.001) and healthy control group (3.55 pg/ml ± 3.76, p<0.0001) .The mean serum levels of IL-23 in PU, AS and control groups were 8.66 pg/ml ± 8.41, 7.25 pg/ml ± 5.66 and 3.64 pg/ml ± 3.36, respectively .The mean serum levels of IL-23 in PU and AS groups was significantly higher than those found in uninfected control group (P<0.02 and P<0.03, respectively).
Conclusion: The results of the present study showed higher serum concentrations of IL-17 and IL-23 in H.pylori-infected subjects as compared with control group.

 
Keyword(s): HELICOBACTER PYLORI, PEPTIC ULCER, IL-17, IL-23
 
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