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Paper Information

Journal:   JOURNAL OF MICROBIAL BIOTECHNOLOGY   FALL 2009 , Volume 1 , Number 2 (2); Page(s) 31 To 36.
 
Paper: 

Evaluation Of The Serum Il-17 And Il-23 Levels In Helicobacter Pylori-Infected Peptic Ulcer Patients

 
 
Author(s):  Jafarzadeh A.A.*, Mirzaei V., Nemati M., Rezayati M.T, Ahmad Beygi H.
 
* DEPARTMENT OF MICROBIOLOGY AND IMMUNOLOGY, MEDICAL SCHOOL, RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES
 
Abstract: 
Background and Objective: H.pylori is a major etiologic agent for several gastroduoedenal diseases including gastric ulcer and peptic ulcer. It has been reported that the Th17 cells strongly associated with inflammatory disease and IL-23 presented as a main inducer of Th17 cells development. The aim of this study was to investigate the serum levels of IL-17 and IL-23 in H. pylori-infected peptic ulcer (PU) patients and H. pylori-infected asymptomatic (AS) carriers.Materials and Methods: Totally, 45 H. pylori-infected PU patients, 30 H. pylori-infected AS carriers and 15 healthy uninfected subjects (as a control group) were enrolled to study. A blood sample was obtained from all participants and the serum levels of IL-17 and IL-23 was measured by ELISA method. Results: The mean serum levels of IL-17 in total PU patients (9.28 pg/ml ± 5.48) was significantly higher than those observed in total AS subjects (5.19 pg/ml ± 3.75, p<0.001) and healthy control group (3.55 pg/ml ± 3.76, p<0.0001) .The mean serum levels of IL-23 in PU, AS and control groups were 8.66 pg/ml ± 8.41, 7.25 pg/ml ± 5.66 and 3.64 pg/ml ± 3.36, respectively .The mean serum levels of IL-23 in PU and AS groups was significantly higher than those found in uninfected control group (P<0.02 and P<0.03, respectively). Conclusion: The results of the present study showed higher serum concentrations of IL-17 and IL-23 in H.pylori-infected subjects as compared with control group.
 
Keyword(s): HELICOBACTER PYLORI, PEPTIC ULCER, IL-17, IL-23
 
 
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APA: Copy

JAFARZADEH, A., & MIRZAEI, V., & NEMATI, M., & REZAYATI, M., & AHMAD BEYGI, H. (2009). EVALUATION OF THE SERUM IL-17 AND IL-23 LEVELS IN HELICOBACTER PYLORI-INFECTED PEPTIC ULCER PATIENTS. JOURNAL OF MICROBIAL BIOTECHNOLOGY, 1(2 (2)), 31-36. https://www.sid.ir/en/journal/ViewPaper.aspx?id=189553



Vancouver: Copy

JAFARZADEH A.A., MIRZAEI V., NEMATI M., REZAYATI M.T, AHMAD BEYGI H.. EVALUATION OF THE SERUM IL-17 AND IL-23 LEVELS IN HELICOBACTER PYLORI-INFECTED PEPTIC ULCER PATIENTS. JOURNAL OF MICROBIAL BIOTECHNOLOGY. 2009 [cited 2022January19];1(2 (2)):31-36. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=189553



IEEE: Copy

JAFARZADEH, A., MIRZAEI, V., NEMATI, M., REZAYATI, M., AHMAD BEYGI, H., 2009. EVALUATION OF THE SERUM IL-17 AND IL-23 LEVELS IN HELICOBACTER PYLORI-INFECTED PEPTIC ULCER PATIENTS. JOURNAL OF MICROBIAL BIOTECHNOLOGY, [online] 1(2 (2)), pp.31-36. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=189553.



 
 
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