Paper Information

Journal:   JOURNAL OF THE IRANIAN CHEMICAL SOCIETY(JICS)   DECEMBER 2010 , Volume 7 , Number 4; Page(s) 883 To 889.
 
Paper: 

ENZYMATIC RESOLUTION OF RACEMIC SULCATOL BY LIPASE FROM CANDIDA ANTARCTICA IN A LARGE SCALE

 
 
Author(s):  FERREIRA H.V., ROCHA L.C., SEVERINO R.P., VIANA R.B., DA SILVA A.B.F., PORTO A.L.M.*
 
* INSTITUTO DE QUÍMICA DE SÃO CARLOS, UNIVERSIDADE DE SÃO PAULO, AV. TRABALHADOR SÃO-CARLENSE, 400, CEP 13560-970, SÃO CARLOS, SP, BRAZIL
 
Abstract: 

Large scale enzymatic resolution of racemic sulcatol 2 has been useful for stereoselective biocatalysis. This reaction was fast and selective, using vinyl acetate as donor of acyl group and lipase from Candida antarctica (CALB) as catalyst. The large scale reaction (5.0 g, 39 mmol) afforded high optical purities for S-(+) -sulcatol 2 and R-(+) -sulcatyl acetate 3, i. e. , ee > 99 per cent and good yields (45 per cent) within a short time (40 min). Thermodynamic parameters for the chemoesterification of sulcatol 2 by vinyl acetate were evaluated. The enthalpy and Gibbs free energy values of this reaction were negative, indicating that this process is exothermic and spontaneous which is in agreement with the reaction obtained enzymatically.

 
Keyword(s): ENZYMATIC RESOLUTION, LIPASE, CANDIDA ANTARCTICA, SULCATOL, BIOCATALYSIS
 
References: 
  • ندارد
 
  pdf-File tarjomyar Yearly Visit 81
 
Latest on Blog
Enter SID Blog